Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in
non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium …

In the cell, proteins are synthesized from N to C terminus and begin to fold during translation.
Cotranslational folding mechanisms are therefore linked to elongation rate, which varies as …

Pathogenic mycobacteria cause chronic and acute diseases ranging from human
tuberculosis (TB) to nontubercular infections. Mycobacterium tuberculosis causes both acute …

The protein networks of cell-wall-biosynthesis assemblies are largely unknown. A key class
of enzymes in these assemblies is the lytic transglycosylases (LTs), of which eleven exist in …

Most bacterial ORFs are identified by automated prediction algorithms. However, these
algorithms often fail to identify ORFs lacking canonical features such as a length of> 50 …

ABSTRACT N-terminal protein acetylation is a ubiquitous post-translational modification that
impacts diverse cellular processes in higher organisms. Bacterial proteins are also N …

Bacteria transport proteins to diverse intracellular or extracellular locations to ensure proper
function. Proteins are localized intracellularly to the cytoplasm or the periplasm or …

The ESX-1, type VII, secretion system represents the major virulence determinant of
Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here, by …

Mycobacterium tuberculosis, the cause of human tuberculosis, and Mycobacterium
marinum, a nontubercular pathogen with a broad host range, require the ESX-1 secretion …

Pathogenic mycobacteria use the ESX-1 secretion system to escape the macrophage
phagosome and survive infection. We demonstrated that the ESX-1 system is regulated by …