The signal pathways and treatment of cytokine storm in COVID-19
L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …
and is more devastating than any other previous infectious disease. It has affected a …
Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies
The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …
maintaining multiorgan health and homeostasis. Endothelial functions in health include …
Infectious Diseases Society of America Guidelines on the treatment and management of patients with coronavirus disease 2019 (COVID-19)
Background There are many pharmacologic therapies that are being used or considered for
treatment of coronavirus disease 2019 (COVID-19). There is a need for frequently updated …
treatment of coronavirus disease 2019 (COVID-19). There is a need for frequently updated …
Targeting the NLRP3 inflammasome in cardiovascular diseases
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
Hyperinflammatory immune response and COVID-19: a double edged sword
LY Tan, TV Komarasamy… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease-19 (COVID-19) elicited by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has caused devastating health, economic and social impact …
coronavirus 2 (SARS-CoV-2) has caused devastating health, economic and social impact …
The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options
S Choudhary, K Sharma, O Silakari - Microbial pathogenesis, 2021 - Elsevier
Abstract COVID-19, caused by SARS-CoV-2, emerged as the deadliest outbreak that has
now become a serious health issue to mankind. Activation of inflammatory signaling …
now become a serious health issue to mankind. Activation of inflammatory signaling …
Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications
A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
Clonal expansion and activation of tissue-resident memory-like TH17 cells expressing GM-CSF in the lungs of patients with severe COVID-19
Hyperinflammation contributes to lung injury and subsequent acute respiratory distress
syndrome with high mortality in patients with severe coronavirus disease 2019 (COVID-19) …
syndrome with high mortality in patients with severe coronavirus disease 2019 (COVID-19) …
COVID-19-associated opportunistic infections: a snapshot on the current reports
Abstract Treatment of the novel Coronavirus Disease 2019 (COVID-19) remains a
complicated challenge, especially among patients with severe disease. In recent studies …
complicated challenge, especially among patients with severe disease. In recent studies …
Inflammasome formation in the lungs of patients with fatal COVID-19
S Toldo, R Bussani, V Nuzzi, A Bonaventura… - Inflammation …, 2021 - Springer
Objective The orf8b protein of the coronavirus SARS-CoV, analogous to SARS-CoV-2,
triggers the NLRP3 inflammasome in macrophages in vitro. Deregulated inflammasome …
triggers the NLRP3 inflammasome in macrophages in vitro. Deregulated inflammasome …