The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

Background: Parkinson's disease is an aggressive and progressive neurodegenerative
disorder that depletes dopamine (DA) in the central nervous system. Dopamine replacement …

Levodopa, a dopamine precursor, is an effective and well-tolerated dopamine replacement
agent used to treat Parkinson's disease (PD). Oral levodopa has been widely used for over …

Objectives To assess the feasibility, safety and outcomes of playing Microsoft Kinect
Adventures™ for people with Parkinson's disease in order to guide the design of a …

Brain-derived neurotrophic factor (BDNF) regulates a variety of biological processes
predominantly via binding to the transmembrane receptor tyrosine kinase TrkB. It is a …

Neurodegenerative diseases, such as Alzheimer′ s disease and Parkinson′ s disease
represent a huge unmet medical need. The prevalence of both diseases is increasing, but …

Purpose To prepare an angiopep-conjugated dendrigraft poly-L-lysine (DGL)-based gene
delivery system and evaluate the neuroprotective effects in the rotenone-induced chronic …

Schisantherin A (SA) is a promising anti-Parkinsonism natural product. However, its poor
water solubility and rapid serum clearance impose significant barriers to delivery of SA to the …

In the present study, we have prepared microRNA (miR)-124-loaded Rabies virus
glycoprotein (RVG) 29 surface-conjugated polymeric nanoparticles (NPs) to improve …

l-3, 4-Dihydroxyphenylalanine (l-DOPA) is widely used in the treatment of Parkinson's
disease. Fe3O4 magnetic nanoparticles decorated with ethylenediaminetetraacetic acid …