Monogenic diabetes refers to diabetes mellitus (DM) caused by a mutation in a single gene
and accounts for approximately 1%–5% of diabetes. Correct diagnosis is clinically critical for …

Abstract Potassium channels (K+-channels) selectively control the passive flow of potassium
ions across biological membranes and thereby also regulate membrane excitability. Genetic …

Genes underneath signals from genome-wide association studies (GWAS) for kidney
function are promising targets for functional studies, but prioritizing variants and genes is …

Broad heterogeneity in pancreatic β-cell function and morphology has been widely reported.
However, determining which components of this cellular heterogeneity serve a diabetes …

Understanding the genetic factors of diabetes is essential for addressing the global increase
in type 2 diabetes. HNF1A mutations cause a monogenic form of diabetes called maturity …

Diabetes, a disease characterized by hyperglycemia, has a serious impact on the lives and
families of patients as well as on society. Diabetes is a group of highly heterogeneous …

Heterozygous HNF1A gene mutations can cause maturity onset diabetes of the young 3
(MODY3), characterized by insulin secretion defects. However, specific mechanisms of …

Genome-wide association studies have identified 240 independent loci associated with type
2 diabetes (T2D) risk, but this knowledge has not advanced precision medicine. In contrast …

MODY (Maturity Onset Diabetes of the Young) is a type of diabetes resulting from a
pathogenic effect of gene mutations. Up to date, 13 MODY genes are known. Gene HNF1A …

Abstract Purpose of Review Monogenic forms of diabetes have specific treatments that differ
from the standard care provided for type 1 and type 2 diabetes, making the appropriate …