Background: To promote model-informed precision dosing (MIPD) for vancomycin (VCM),
we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical …

Purpose Voriconazole, an antifungal drug, is metabolized by a cytochrome P450 isozyme.
Increased adverse effects are observed in Asians because of the high rate of poor …

Abstract Model‐informed precision dosing (MIPD) approaches typically apply maximum a
posteriori (MAP) Bayesian estimation to determine individual pharmacokinetic (PK) …

Background Precision dosing programs are promising tools for optimising antimicrobial
dosing. Selecting the ideal program for local application may be challenging due to the large …

Children show important developmental and maturational changes, which may contribute
greatly to pharmacokinetic (PK) variability observed in pediatric patients. These PK …

Background: With increasing knowledge of beta-lactam pharmacodynamics and interpatient
and intrapatient variability in pharmacokinetics, the usefulness of therapeutic drug …

Aminoglycosides are broad-spectrum antibiotics largely used in children, but they have
potential toxic side effects, including ototoxicity. Ototoxicity from aminoglycosides is …

In the era of “Bad Bugs, No Drugs,” optimizing antibiotic therapy against multi-drug resistant
(MDR) pathogens is crucial. Mathematical modelling has been employed to further optimize …

Late-onset neonatal sepsis (LONS) remains an important threat to the health of preterm
neonates in the neonatal intensive care unit. Strategies to optimize care for preterm …

As one of the efficient techniques for TDM, the population pharmacokinetic (popPK) model
approach for dose individualization has been developed due to the rapidly growing …