Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …

Drug transporters can govern the absorption, distribution, metabolism, and excretion of
substrate drugs and endogenous substances. Investigations to examine their potential …

Many drug–drug interactions (DDI s) are based on alterations of the plasma concentrations
of a victim drug due to another drug causing inhibition and/or induction of the metabolism or …

Phase 0 approaches—which include microdosing—evaluate subtherapeutic exposures of
new drugs in first-in-human studies known as exploratory clinical trials. Recent progress …

A large body of evidence suggests that not only direct anticoagulant effects but also major
bleeding events and stroke prevention depend on plasma concentrations of direct oral …

Purpose: The increasing burden of invasive fungal infections results in growing challenges
to antifungal (AF) therapeutic drug monitoring (TDM). This review aims to provide an …

Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …

Abstract Background and Objectives Darolutamide is a novel androgen receptor (AR)
antagonist approved for the treatment of nonmetastatic castration-resistant prostate cancer …

Drug transporters are critically important for the absorption, distribution, metabolism, and
excretion (ADME) of many drugs and endogenous compounds. Therefore, disruption of …

Drug–drug interactions (DDIs) caused by the co‐administration of multiple drugs are major
safety concerns in the clinic. Several drugs have been withdrawn from the market due to …