Background: Cisplatin (Cp) is an antineoplastic agent with a dose-limiting nephrotoxicity. Cp-
induced nephrotoxicity is characterized by the interplay of oxidative stress, inflammation …

Nicotine is one of the primary components in cigarettes, which is responsible for addiction.
Numerous studies have investigated the effects of nicotine on pulmonary disease. The …

The way of cell death can be roughly divided into two categories: cell necrosis and PCD
(programmed cell death). Pyroptosis is a kind of PCD, its occurrence depends on the …

Pyroptosis is a newly discovered form of programmed cell death, which is manifested by
DNA fragmentation, cell swelling, cell membrane rupture and leakage of cell contents …

Pyroptosis is a type of programmed cell death (PCD) accompanied by an inflammatory
reaction and the rupture of a membrane. Pyroptosis is divided into a canonical pathway …

Pyroptosis is a form of regulated cell death mediated by the gasdermin protein family. During
virus infection, cell pyroptosis restricts viral replication. The mechanisms of the tripartite motif …

Background: Increasing evidence shows that GSDME is involved in tumor chemotherapy.
Lobaplatin is an important chemotherapy drug for the treatment of cervical cancer. However …

Cancer is a major public health problem that threatens human life worldwide. In recent
years, immunotherapy has made great progress in both clinical and laboratory research. But …

Cordyceps militaris (CM) is traditionally used as dietary therapy for lung cancer patients in
China. CM extract (CME) is hydrosoluble fraction of CM and extensively investigated …

Pyroptosis is an inflammatory type of regulated cell death that is dependent on
inflammasome activation and downstream proteases such as caspase-1 or caspase 4/5/11 …