Abstract The Polycomb group (PcG) proteins are transcriptional repressors that regulate
lineage choices during development and differentiation. Recent studies have advanced our …

Myeloproliferative neoplasms (MPNs) are clonal disorders characterized by excessive
production of mature blood cells. In the majority of classic MPN—polycythemia vera …

The commensal microbiota impacts specific immune cell populations and their functions at
peripheral sites, such as gut mucosal tissues. However, it remains unknown whether gut …

Recent studies indicate that IL-1α functions intracellularly in pathways independent of its cell
surface receptors by translocating to the nucleus and regulating transcription. Similarly, the …

The aryl hydrocarbon receptor (AhR) participates in the differentiation of mouse regulatory T
cells (Treg cells) and interleukin 17 (IL-17)-producing helper T cells (TH17 cells), but its role …

Background & Aims Although Ikaros (IKZF1) is a well-established transcriptional regulator in
leukocyte lymphopoiesis and differentiation, its role in myeloid innate immune responses …

Recent discoveries suggest that the critical events leading to the anti-proliferative activity of
the IMiD immunomodulatory agents lenalidomide and pomalidomide in multiple myeloma …

It has become apparent that chromatin modification plays a critical role in the regulation of
cell-type-specific gene expression. Here, we show that an inhibitor of histone deacetylase …

Lineage specification of multipotent progenitor cells is governed by a balance of lineage-
affiliated transcription factors, such as GATA1 and PU. 1, which regulate the choice between …

The generation of B-lymphocytes from hematopoietic stem cells is controlled by multiple
transcription factors regulating distinct developmental aspects. Ikaros and PU. 1 act in …