Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

The vast interindividual clinical variability observed in any microbial infection—ranging from
silent infection to lethal disease—is increasingly being explained by human genetic and …

The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …

The gut microbiome is at the center of inflammatory bowel disease (IBD) pathogenesis and
disease activity. While this has mainly been studied in the context of the bacterial …

Antibodies mediate natural and vaccine-induced immunity against viral and bacterial
pathogens, whereas fungi represent a widespread kingdom of pathogenic species for which …

It was first demonstrated in the late nineteenth century that human deaths from fever were
typically due to infections. As the germ theory gained ground, it replaced the old, unproven …

Caspase-recruitment domain 9 (CARD9) protein is expressed in many cells especially in
immune cells, and is critically involved in the function of the innate and adaptive immune …

Abstract Seminal work by Louis Pasteur revealed the contribution of fungi–yeasts and
microsporidia to agroindustry and disease in animals, respectively. More than 150 years …

Dermatophytoses (ringworms) are among the most frequent skin infections and are a highly
prevalent cause of human disease worldwide. Despite the incidence of these superficial …

Candida species, including C. albicans in particular, can cause superficial or invasive
disease, often in patients with known acquired immunodeficiencies or iatrogenic conditions …