[HTML][HTML] Long COVID: the nature of thrombotic sequelae determines the necessity of early anticoagulation

C Wang, C Yu, H Jing, X Wu, VA Novakovic… - Frontiers in Cellular …, 2022 - frontiersin.org
Many discharged COVID-19 patients affected by sequelae experience reduced quality of life
leading to an increased burden on the healthcare system, their families and society at large …

[HTML][HTML] Stem cell-derived extracellular vesicles as new tools in regenerative medicine-immunomodulatory role and future perspectives

E Karnas, P Dudek, EK Zuba-Surma - Frontiers in immunology, 2023 - frontiersin.org
In the last few decades, the practical use of stem cells (SCs) in the clinic has attracted
significant attention in the regenerative medicine due to the ability of these cells to proliferate …

[HTML][HTML] Extracellular vesicles linking inflammation, cancer and thrombotic risks

S Beck, B Hochreiter, JA Schmid - Frontiers in cell and developmental …, 2022 - frontiersin.org
Extracellular vesicles (EVs) being defined as lipid-bilayer encircled particles are released by
almost all known mammalian cell types and represent a heterogenous set of cell fragments …

Extracellular vesicle-based therapy for COVID-19: promises, challenges and future prospects

V Karn, S Ahmed, LW Tsai, R Dubey, S Ojha, HN Singh… - Biomedicines, 2021 - mdpi.com
The COVID-19 pandemic has become a serious concern and has negatively impacted
public health and the economy. It primarily targets the lungs, causing acute respiratory …

COVID-19 inflammation and implications in drug delivery

M Zoulikha, F Huang, Z Wu, W He - Journal of Controlled Release, 2022 - Elsevier
Growing evidence indicates that hyperinflammatory syndrome and cytokine storm observed
in COVID-19 severe cases are narrowly associated with the disease's poor prognosis …

Mesenchymal stem cell-derived extracellular vesicles for therapeutic use and in bioengineering applications

C McLaughlin, P Datta, YP Singh, A Lo, S Horchler… - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) are small lipid bilayer-delimited particles that are naturally
released from cells into body fluids, and therefore can travel and convey regulatory functions …

Targeted drug delivery to the central nervous system using extracellular vesicles

L Zhou, S Kodidela, S Godse, S Thomas-Gooch… - Pharmaceuticals, 2022 - mdpi.com
The blood brain barrier (BBB) maintains the homeostasis of the central nervous system
(CNS) and protects the brain from toxic substances present in the circulating blood …

Potential therapeutic applications of extracellular vesicles in the immunopathogenesis of COVID-19

M Motallebnezhad, M Omraninava, HEG Ghaleh… - … -Research and Practice, 2023 - Elsevier
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the cause of
coronavirus disease 2019 (COVID-19) which has emerged as a global health crisis …

Circulating extracellular particles from severe COVID-19 patients show altered profiling and innate lymphoid cell-modulating ability

D Forte, RM Pellegrino, S Trabanelli, T Tonetti… - Frontiers in …, 2023 - frontiersin.org
Introduction Extracellular vesicles (EVs) and particles (EPs) represent reliable biomarkers
for disease detection. Their role in the inflammatory microenvironment of severe COVID-19 …

Extracellular Vesicles as a Translational Approach for the Treatment of COVID-19 Disease: An Updated Overview

E Serretiello, A Ballini, A Smimmo, M Acunzo, M Raimo… - Viruses, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic
in the years 2020–2022. With a high prevalence, an easy route of transmission, and a long …