Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

The HIV-1 virion structural polyprotein, Gag, is directed to particle assembly sites at the
plasma membrane by its N-terminal matrix (MA) domain. MA also binds to host tRNAs. To …

During the late phase of HIV type 1 (HIV-1) infection cycle, the virally encoded Gag
polyproteins are targeted to the inner leaflet of the plasma membrane (PM) for assembly …

Advancement in drug therapies and patient care have drastically improved the mortality
rates of HIV-1 infected individuals. Many of these therapies were developed or improved …

Host factor tRNAs facilitate the replication of retroviruses such as human immunodeficiency
virus type 1 (HIV-1). HIV-1 uses human tRNALys3 as the primer for reverse transcription …

Plasma-membrane-specific localization of Gag, an essential step in HIV-1 particle assembly,
is regulated by the interaction of the Gag MA domain with PI (4, 5) P 2 and tRNA-mediated …

The HIV-1 structural polyprotein Gag drives the virus particle assembly specifically at the
plasma membrane (PM). During this process, the nascent virion incorporates specific …

Human immunodeficiency virus type 1 (HIV-1) trans-activator of transcription (Tat) is a small,
intrinsically disordered basic protein that plays diverse roles in the HIV-1 replication cycle …

During the late phase of HIV-1 infection, viral Gag polyproteins are targeted to the plasma
membrane (PM) for assembly. Gag localization at the PM is a prerequisite for the …