A large family of chromatin remodelers that noncovalently modify chromatin is crucial in cell
development and differentiation. They are often the targets of cancer, neurological disorders …

Nucleosomes, the basic organizational units of chromatin, package and regulate eukaryotic
genomes. ATP-dependent nucleosome-remodeling factors endow chromatin with structural …

The prokaryotic CRISPR (clustered regularly interspaced palindromic repeats)-associated
protein, Cas9, has been widely adopted as a tool for editing, imaging, and regulating …

Chromatin-remodelling complexes (CRCs) mobilize nucleosomes to mediate the access of
DNA-binding factors to their sites in vivo. These CRCs contain a catalytic subunit that bears …

ATP-dependent chromatin remodelling enzymes (remodellers) regulate DNA accessibility in
eukaryotic genomes. Many remodellers reposition (slide) nucleosomes, however, how DNA …

Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by
alignment to reference sites like active promoters. How the distances between nucleosomes …

Chromatin remodelers use the energy of ATP hydrolysis to reposition or evict nucleosomes
or to replace canonical histones with histone variants. By regulating nucleosome dynamics …

Despite their canonical two-fold symmetry, nucleosomes in biological contexts are often
asymmetric: functionalized with post-translational modifications (PTMs), substituted with …

As superfamily 2 (SF2)-type translocases, chromatin remodelers are expected to use an
inchworm-type mechanism to walk along DNA. Yet how they move DNA around the histone …

Chromatin remodelers use a helicase-like ATPase motor to reposition and reorganize
nucleosomes along genomic DNA. Yet, how the ATPase motor communicates with other …