[HTML][HTML] Senescent cardiac fibroblasts: a key role in cardiac fibrosis

JM Osorio, C Espinoza-Pérez, C Rimassa-Taré… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Cardiac fibroblasts are a cell population that controls the homeostasis of the extracellular
matrix and orchestrates a damage response to maintain cardiac architecture and …

Multifaceted effects of obesity on cancer immunotherapies: bridging preclinical models and clinical data

LV Vick, RJ Canter, AM Monjazeb… - Seminars in cancer biology, 2023 - Elsevier
Obesity, defined by excessive body fat, is a highly complex condition affecting numerous
physiological processes, such as metabolism, proliferation, and cellular homeostasis. These …

[HTML][HTML] HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases

X Zheng, J Lu, J Liu, L Zhou, Y He - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Cardiovascular disease (CVD) is the most fatal disease that causes sudden death, and
inflammation contributes substantially to its occurrence and progression. The prevalence of …

Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves from Olea europaea

DM Ferreira, NM de Oliveira, MH Chéu, D Meireles… - Plants, 2023 - mdpi.com
Olea europaea L. folium merits further exploration of the potential of its substrates for
therapeutic supplements. Quantitative and qualitative analyses were conducted on samples …

Novel biomarkers for inflammatory bowel disease and colorectal cancer: an interplay between metabolic dysregulation and excessive inflammation

M Salla, J Guo, H Joshi, M Gordon, H Dooky… - International Journal of …, 2023 - mdpi.com
Persistent inflammation can trigger altered epigenetic, inflammatory, and bioenergetic
states. Inflammatory bowel disease (IBD) is an idiopathic disease characterized by chronic …

Mechanisms and effects of metformin on skeletal muscle disorders

R Shang, J Miao - Frontiers in Neurology, 2023 - frontiersin.org
Skeletal muscle disorders are mostly genetic and include several rare diseases. With
disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The …

Metformin as a promising target for DPP4 expression: computational modeling and experimental validation

AA El-Arabey, H Zhang, M Abdalla, ST Al-Shouli… - Medical Oncology, 2023 - Springer
Metformin is a regularly prescribed and low-cost generic medication. Metformin has been
proposed as a target for Dipeptidyl-peptidase 4 (DPP4) expression in various clinical …

[HTML][HTML] Metformin induces autophagy of cisplatin-resistant human gastric cancer cells in addition to apoptosis

CW Fang, JS Yang, JH Chiang, PC Shieh, FJ Tsai… - BioMedicine, 2023 - ncbi.nlm.nih.gov
Metformin has been used to treat cases of type 2 diabetes mellitus, and mounting studies
have shown that metformin can act alone or in synergy with other anticancer agents to …

[HTML][HTML] Elucidation of the anti-β-cell dedifferentiation mechanism of a modified Da Chaihu Decoction by an integrative approach of network pharmacology and …

H Chen, J Guo, Y Cai, C Zhang, F Wei, H Sun… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Modified Da Chaihu decoction (MDCH) is a
traditional Chinese herbal prescription that has been used in the clinic to treat type 2 …

The impact of metformin use on the outcomes of relapse-remitting multiple sclerosis patients receiving interferon beta 1a: an exploratory prospective phase II open …

MY Abdelgaied, MH Rashad, HM El-Tayebi… - Journal of …, 2024 - Springer
Background Multiple sclerosis (MS) is a chronic demyelinating neurodegenerative disorder.
Elevated levels of pro-inflammatory mediators and some oxidative stress parameters can …