Inherited retinal diseases: linking genes, disease-causing variants, and relevant therapeutic modalities

N Schneider, Y Sundaresan, P Gopalakrishnan… - Progress in retinal and …, 2022 - Elsevier
Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …

Early and late stage gene therapy interventions for inherited retinal degenerations

C Botto, M Rucli, MD Tekinsoy, J Pulman… - Progress in Retinal and …, 2022 - Elsevier
Inherited and age-related retinal degeneration is the hallmark of a large group of
heterogeneous diseases and is the main cause of untreatable blindness today. Genetic …

Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses

L Jiang, G Lu, Y Zeng, Y Sun, H Kang, J Burford… - Nature …, 2022 - nature.com
Electronic visual prostheses, or biomimetic eyes, have shown the feasibility of restoring
functional vision in the blind through electrical pulses to initiate neural responses artificially …

Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives

MF Dias, K Joo, JA Kemp, SL Fialho… - Progress in retinal and …, 2018 - Elsevier
Retinitis Pigmentosa (RP) is a hereditary retinopathy that affects about 2.5 million people
worldwide. It is characterized with progressive loss of rods and cones and causes severe …

Simultaneous assessment of the whole eye biomechanics using ultrasonic elastography

R Li, X Qian, C Gong, J Zhang, Y Liu… - IEEE Transactions …, 2022 - ieeexplore.ieee.org
Objective: Current elastography techniques in the field of ophthalmology usually target one
specific tissue, such as the cornea or the sclera. However, the eye is an inter-related organ …

[HTML][HTML] The X-linked retinopathies: physiological insights, pathogenic mechanisms, phenotypic features and novel therapies

SR De Silva, G Arno, AG Robson, A Fakin… - Progress in retinal and …, 2021 - Elsevier
X-linked retinopathies represent a significant proportion of monogenic retinal disease. They
include progressive and stationary conditions, with and without syndromic features. Many …

An update on retinal prostheses

LN Ayton, N Barnes, G Dagnelie, T Fujikado… - Clinical …, 2020 - Elsevier
Retinal prostheses are designed to restore a basic sense of sight to people with profound
vision loss. They require a relatively intact posterior visual pathway (optic nerve, lateral …

Microbial rhodopsins: diversity, mechanisms, and optogenetic applications

EG Govorunova, OA Sineshchekov, H Li… - Annual review of …, 2017 - annualreviews.org
Microbial rhodopsins are a family of photoactive retinylidene proteins widespread
throughout the microbial world. They are notable for their diversity of function, using …

[HTML][HTML] Neuroprotective strategies for retinal disease

MT Pardue, RS Allen - Progress in retinal and eye research, 2018 - Elsevier
Diseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and
glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of …

[HTML][HTML] Cell types and cell circuits in human and non-human primate retina

U Grünert, PR Martin - Progress in retinal and eye research, 2020 - Elsevier
This review summarizes our current knowledge of primate including human retina focusing
on bipolar, amacrine and ganglion cells and their connectivity. We have two main …