Telomerase, a specialized ribonucleoprotein enzyme complex, maintains telomere length at
the 3′ end of chromosomes, and functions importantly in stem cells, cancer and aging …

Reprogramming of somatic cells is a valuable tool to understand the mechanisms of
regaining pluripotency and further opens up the possibility of generating patient-specific …

Telomerase, consisting of the protein subunit telomerase reverse transcriptase (TERT) and
RNA component TERC, is best known for maintaining and extending human telomeres, the …

Mesenchymal stem cells have been increasingly introduced to have great potential in
regenerative medicine, immunotherapy, and gene therapy due to their unique properties of …

Stroke causes a devastating insult to the brain resulting in severe neurological deficits
because of a massive loss of different neurons and glia. In the United States, stroke is the …

Telomerase reverse transcriptase (TERT) is expressed by quiescent adult stem cells (ASC)
in numerous adult murine and human tissues, but has never been explored in the adult …

Stem cell research holds a promise to treat and prevent age-related degenerative changes
in humans. Literature is replete with studies showing that stem cell function declines with …

Although HIV‐associated neurocognitive disorders (HAND) result from injury and loss of
neurons, productive infection routinely takes place in cells of macrophage lineage. In such a …

Cell senescence is characterized by the irreversible arrest of cell proliferation and has been
implicated as one of the critical causes of Alzheimer's disease, Parkinson's disease, and …

The conversion of healthy stem cells into cancer stem cells (CSCs) is believed to underlie
tumor relapse after surgical removal and fuel tumor growth and invasiveness. CSCs often …