T cell response to SARS-CoV-2 infection in humans: A systematic review

M Shrotri, MCI van Schalkwyk, N Post, D Eddy… - PloS one, 2021 - journals.plos.org
Background Understanding the T cell response to SARS-CoV-2 is critical to vaccine
development, epidemiological surveillance and disease control strategies. This systematic …

[HTML][HTML] The immunology of SARS-CoV-2 infections and vaccines

L Grigoryan, B Pulendran - Seminars in immunology, 2020 - Elsevier
Abstract SARS-CoV-2, the virus that causes COVID-19, emerged in late 2019, and was
declared a global pandemic on March 11th 2020. With over 50 million cases and 1.2 million …

[PDF][PDF] The immunology of multisystem inflammatory syndrome in children with COVID-19

CR Consiglio, N Cotugno, F Sardh, C Pou, D Amodio… - Cell, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very
mild and often asymptomatic in children. A complication is the rare multisystem inflammatory …

Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8+ T cells

A Kusnadi, C Ramírez-Suástegui, V Fajardo… - Science …, 2021 - science.org
The molecular properties of CD8+ T cells that respond to SARS-CoV-2 infection are not fully
known. Here, we report on the single-cell transcriptomes of> 80,000 virus-reactive CD8+ T …

[PDF][PDF] Low-avidity CD4+ T cell responses to SARS-CoV-2 in unexposed individuals and humans with severe COVID-19

P Bacher, E Rosati, D Esser, GR Martini, C Saggau… - Immunity, 2020 - cell.com
CD4+ T cells reactive against SARS-CoV-2 can be found in unexposed individuals, and
these are suggested to arise in response to common cold coronavirus (CCCoV) infection …

[HTML][HTML] Cellular and molecular pathways of COVID-19 and potential points of therapeutic intervention

JP Hussman - Frontiers in pharmacology, 2020 - frontiersin.org
With the objective of linking early findings relating to the novel SARS-CoV-2 coronavirus
with potentially informative findings from prior research literature and to promote …

Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients

J Westmeier, K Paniskaki, Z Karaköse, T Werner… - MBio, 2020 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell
response that most likely contributes to virus control in COVID-19 patients but may also …

[PDF][PDF] Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19

J Neidleman, X Luo, AF George, M McGregor, J Yang… - Cell Reports, 2021 - cell.com
Although T cells are likely players in severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2 …

Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19

A Saris, TDY Reijnders, EJ Nossent, AR Schuurman… - Thorax, 2021 - thorax.bmj.com
Background Knowledge of the pathophysiology of COVID-19 is almost exclusively derived
from studies that examined the immune response in blood. We here aimed to analyse the …

[PDF][PDF] Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2

X An, M Martinez-Paniagua, A Rezvan, SR Sefat… - Iscience, 2021 - cell.com
Despite remarkable progress in the development and authorization of vaccines against
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to validate …