Bioproduction of the recombinant sweet protein thaumatin: Current state of the art and perspectives
There is currently a worldwide trend to reduce sugar consumption. This trend is mostly met
by the use of artificial non-nutritive sweeteners. However, these sweeteners have also been …
by the use of artificial non-nutritive sweeteners. However, these sweeteners have also been …
Unveiling the Intricate Connection: Cell Volume as a Key Regulator of Mechanotransduction
The volumes of living cells undergo dynamic changes to maintain the cells' structural and
functional integrity in many physiological processes. Minor fluctuations in cell volume can …
functional integrity in many physiological processes. Minor fluctuations in cell volume can …
Every breath you take: non-invasive real-time oxygen biosensing in two-and three-dimensional microfluidic cell models
Knowledge on the availability of dissolved oxygen inside microfluidic cell culture systems is
vital for recreating physiological-relevant microenvironments and for providing reliable and …
vital for recreating physiological-relevant microenvironments and for providing reliable and …
[HTML][HTML] Measurement of respiration and acidification rates of mammalian cells in thermoplastic microfluidic devices
B Müller, P Sulzer, M Walch, H Zirath, T Buryška… - Sensors and Actuators B …, 2021 - Elsevier
Luminescent chemical sensors have been proven to be a valuable asset in cell cultures and
generally in microbiological studies. We present microfluidic cell culture devices with …
generally in microbiological studies. We present microfluidic cell culture devices with …
Predictive macroscopic modeling of cell growth, metabolism and monoclonal antibody production: Case study of a CHO fed-batch production
BB Yahia, L Malphettes, E Heinzle - Metabolic Engineering, 2021 - Elsevier
We describe a systematic approach to establish predictive models of CHO cell growth, cell
metabolism and monoclonal antibody (mAb) formation during biopharmaceutical production …
metabolism and monoclonal antibody (mAb) formation during biopharmaceutical production …
Conception and optimization of an ammonia synthesis superstructure for energy storage
Ammonia has a potential as carbon-free and high-energy density compound for chemical
storage of renewable energies and its synthesis from green H 2 requires to be as …
storage of renewable energies and its synthesis from green H 2 requires to be as …
Population balance modelling captures host cell protein dynamics in CHO cell cultures
S Alhuthali, C Kontoravdi - Plos one, 2022 - journals.plos.org
Monoclonal antibodies (mAbs) have been extensively studied for their wide therapeutic and
research applications. Increases in mAb titre has been achieved mainly by cell culture …
research applications. Increases in mAb titre has been achieved mainly by cell culture …
Process analytical technology tools for perfusion cell culture
SM Mercier, PM Rouel, P Lebrun… - Engineering in life …, 2016 - Wiley Online Library
During cell cultivation processes for the production of biopharmaceuticals, good process
performance and good product quality can be ensured by online monitoring of critical …
performance and good product quality can be ensured by online monitoring of critical …
A dynamic model linking cell growth to intracellular metabolism and extracellular by‐product accumulation
Mathematical modeling of animal cell growth and metabolism is essential for the
understanding and improvement of the production of biopharmaceuticals. Models can …
understanding and improvement of the production of biopharmaceuticals. Models can …
Impact of influenza A virus infection on growth and metabolism of suspension MDCK cells using a dynamic model
Cell cultured-based influenza virus production is a viable option for vaccine manufacturing.
In order to achieve a high concentration of viable cells, is requirement to have not only …
In order to achieve a high concentration of viable cells, is requirement to have not only …