Dopamine reduces SARS-CoV-2 replication in vitro through downregulation of D2 receptors and upregulation of type-I interferons

F Limanaqi, S Zecchini, B Dino, S Strizzi, G Cappelletti… - Cells, 2022 - mdpi.com
Recent evidence suggests that SARS-CoV-2 hinders immune responses via dopamine (DA)-
related mechanisms. Nonetheless, studies addressing the specific role of DA in the frame of …

Ribonuclease inhibitor 1 (RNH1) deficiency cause congenital cataracts and global developmental delay with infection-induced psychomotor regression and anemia

C Hedberg-Oldfors, S Mitra, A Molinaro… - European Journal of …, 2023 - nature.com
Ribonuclease inhibitor 1, also known as angiogenin inhibitor 1, encoded by RNH1, is a
ubiquitously expressed leucine-rich repeat protein, which is highly conserved in mammalian …

Characterization and Comparison Analysis of Milk Fat Globule Membrane Proteins between Human and Porcine Milk

H Zhao, X Liu, X Amantai, J Bi, X Cao… - Journal of Agricultural …, 2024 - ACS Publications
This study aimed to explore the differences in milk fat globule membrane (MFGM) proteins
between human milk (HM) and porcine milk (PM) using a label-free quantitative proteomic …

Activation of the NLRP1 inflammasome and its role in transmissible gastroenteritis coronavirus infection

H He, W Wang, L Li, X Zhang, H Shi, J Chen… - Journal of …, 2023 - Am Soc Microbiol
The inflammasome pathway is a critical early response mechanism of the host that detects
pathogens, initiates the production of inflammatory cytokines, and recruits effector cells to …

Ribonuclease inhibitor and angiogenin system regulates cell type–specific global translation

M Stillinovic, MA Sarangdhar, N Andina, A Tardivel… - Science …, 2024 - science.org
Translation of mRNAs is a fundamental process that occurs in all cell types of multicellular
organisms. Conventionally, it has been considered a default step in gene expression …

Leishmania infection upregulates and engages host macrophage Argonaute 1, and system-wide proteomics reveals Argonaute 1-dependent host response

A Moradimotlagh, S Chen, S Koohbor… - Frontiers in …, 2023 - frontiersin.org
Leishmania donovani, an intracellular protozoan parasite, is the causative agent of visceral
leishmaniasis, the most severe form of leishmaniasis in humans. It is becoming increasingly …

Ribonuclease inhibitor 1 emerges as a potential biomarker and modulates inflammation and iron homeostasis in sepsis

C Neu, C Beckers, N Frank, K Thomas, M Bartneck… - Scientific Reports, 2024 - nature.com
Sepsis, marked by organ dysfunction, necessitates reliable biomarkers. Ribonuclease
inhibitor 1 (RNH1), a ribonuclease (RNase) inhibitor, emerged as a potential biomarker for …

Human molecular genetics sheds light on the physiological significance of ribonuclease inhibitor (RNH1)

MA Sarangdhar, N Andina, R Allam - European Journal of Human …, 2023 - nature.com
Ribonuclease inhibitor (RI or RNH1), also known as angiogenin inhibitor 1 (OMIM 173320),
is a 50-kDa protein that is expressed throughout the human tissues [1], with particularly high …

Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy

V Shashi, K Schoch, R Ganetzky, PG Kranz… - Genetics in …, 2023 - Elsevier
Purpose Mendelian etiologies for acute encephalopathies in previously healthy children are
poorly understood, with the exception of RAN binding protein 2 (RANBP2)–associated acute …

Leishmania donovani upregulates host macrophage Argonaute 1 to persist inside infected host, and quantitative proteomic analysis of RNA-induced silencing …

A Moradimotlagh - 2023 - open.library.ubc.ca
Leishmania is a protozoan parasite that causes a wide range of diseases collectively known
as leishmaniasis, which differ in symptoms and severity throughout various clinical forms …