Chromatin remodelers act to regulate multiple cellular processes, such as transcription and
DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers …

As primary carriers of epigenetic information and gatekeepers of genomic DNA,
nucleosomes are essential for proper growth and development of all eukaryotic cells …

DNA wraps around the histone octamer to form nucleosomes, the repeating unit of
chromatin, which create barriers for accessing genetic information. Snf2-like chromatin …

Unlike other chromatin remodelers, INO80 preferentially mobilizes hexasomes, which can
form during transcription. Why INO80 prefers hexasomes over nucleosomes remains …

The RSC complex remodels chromatin structure and regulates gene transcription. We used
cryo–electron microscopy to determine the structure of yeast RSC bound to the nucleosome …

Chromatin remodelers are ATP-dependent enzymes that reorganize nucleosomes within all
eukaryotic genomes. Here we report a complex of the Chd1 remodeler bound to a …

Chromatin is highly dynamic, undergoing continuous global changes in its structure and
type of histone and DNA modifications governed by processes such as transcription, repair …

Abstract The human Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4
syndrome is a severe disease with increased mortality caused by mutation in the LSH gene …

Molecular assembly is the process of organizing individual molecules into larger structures
and complex systems. The self-assembly approach is predominantly utilized in creating …

DNA wraps around histone octamers to assemble nucleosomes, which pack into high-
ordered chromatin structure in the nucleus, and block access to the genetic material. The …