Sexual maturation is a complex physiological process that involves multiple variables, such
as genetic and environmental factors. Among females, age at menarche (AM) is a critical …

Background Syndromic ciliopathies are a group of congenital disorders characterized by
broad clinical and genetic overlap, including obesity, visual problems, skeletal anomalies …

Background Cigarette smoking and particulate matter (PM) with aerodynamic diameter< 2.5
μm (PM2. 5) are major preventable cardiovascular mortality and morbidity promoters. Their …

Recessive variants in GJB2 are the most important genetic cause of sensorineural hearing
impairment (SNHI) worldwide. Phenotypes vary significantly in GJB2-related SNHI, even in …

Summary Type 2 diabetes (T2D) and hypertension are common comorbidities and, along
with hyperlipidemia, serve as risk factors for cardiovascular diseases. This study aimed to …

Truncus Arteriosus (TA) is a congenital heart disease characterized by a single common
blood vessel emerging from the right and left ventricles instead of the main pulmonary artery …

Purpose: The purpose of this study was to conduct a large-scale genome-wide association
study (GWAS) and construct a polygenic risk score (PRS) for risk stratification in patients with …

Background Family history of gout and sex are independently associated with gout.
However, there is a paucity of research regarding the joint role of both factors in gout …

Abstract Chronic Obstructive Pulmonary Disease (COPD) and periodontal disease have
been linked to higher levels of particulate matter, including PM 10. Our study examined the …

Background Hepatitis B (HBV) and hepatitis C (HCV) viruses are diseases of global public
health concern and are associated with liver cancer. Recent studies have revealed …