Interleukin 6 and its receptor: ten years later

T Hirano - International reviews of immunology, 1998 - Taylor & Francis
Ten years have passed since the molecular cloning of interleukin 6 (IL-6) in 1986. IL-6 is a
typical cytokine, exhibiting functional pleiotropy and redundancy. IL-6 is involved in the …

Aptamers against pro-and anti-inflammatory cytokines: a review

M Boshtam, S Asgary, S Kouhpayeh, L Shariati… - Inflammation, 2017 - Springer
Inflammatory disorders result from continuous inflammation in injured sites. Many molecules
are involved in this process; the inhibition of which could prevent the inflammation …

Interleukin-11: review of molecular, cell biology, and clinical use

X Du, DA Williams - Blood, The Journal of the American Society …, 1997 - ashpublications.org
F weights of recombinant human (rh) and murine IL-11 are 19,144 daltons6 and 19,154
daltons, 2 respectively. Mature IRST ISOLATED IN 1990, interleukin-11 (IL-11) has proven to …

IL-6 cytokine family and signal transduction: a model of the cytokine system

M Hibi, K Nakajima, T Hirano - Journal of molecular medicine, 1996 - Springer
Abstract The interleukin 6 (IL-6) cytokine family, which includes IL-6, leukemia inhibitory
factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), IL-11 and cardiotrophin …

Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily

T Hirano, T Matsuda, K Nakajima - Stem cells, 1994 - Wiley Online Library
Abstract Interleukin 6 (IL‐6) and related cytokines, such as leukemia inhibitory factor (LIF),
oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL‐11 exhibit multiple functions …

Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness.

O Einarsson, GP Geba, Z Zhu… - The Journal of …, 1996 - Am Soc Clin Investig
To address the role of IL-11 in viral airways dysfunction, we determined whether infectious
agents that exacerbate asthma stimulate stromal cell IL-11 production, determined whether …

Hematopoietic, immunomodulatory and epithelial effects of interleukin-11

US Schwertschlag, WL Trepicchio, KH Dykstra… - Leukemia, 1999 - nature.com
Abstract Interleukin 11 (IL-11) is a pleiotropic cytokine with biological activities on many
different cell types. Recombinant human IL-11 (rhIL-11) is produced by recombinant DNA …

More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer

T Putoczki, M Ernst - Journal of leukocyte biology, 2010 - academic.oup.com
Review discusses newly emerging role for IL-11 in inflammation-associated cancers of the
gastrointestinal tract. IL-11, a member of the IL-6 family of cytokines, exerts pleiotropic …

Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction.

W Tang, GP Geba, T Zheng, P Ray… - The Journal of …, 1996 - Am Soc Clin Investig
Interleukin-11 is a pleotropic cytokine produced by lung stromal cells in response to
respiratory viruses, cytokines, and histamine. To further define its potential effector functions …

Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment

XX Du, DA Williams - 1994 - ashpublications.org
IL-11 is a unique growth factor derived from cells making up the HM. Although cloned based
on IL-6-like bioactivity, IL-11 and IL-6 have distinct biologic profiles (Table 1). IL-11, like …