Exosomes as mediators of intercellular crosstalk in metabolism

R Isaac, FCG Reis, W Ying, JM Olefsky - Cell metabolism, 2021 - cell.com
Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …

Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

Reexamining assumptions about miRNA-guided gene silencing

A Kilikevicius, G Meister, DR Corey - Nucleic acids research, 2022 - academic.oup.com
MicroRNAs (miRNAs) are short endogenously expressed RNAs that have the potential to
regulate the expression of any RNA. This potential has led to the publication of several …

DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA–gene interactions

D Karagkouni, MD Paraskevopoulou… - Nucleic acids …, 2018 - academic.oup.com
Abstract DIANA-TarBase v8 (http://www. microrna. gr/tarbase) is a reference database
devoted to the indexing of experimentally supported microRNA (miRNA) targets. Its eighth …

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

M Piwecka, P Glažar, LR Hernandez-Miranda… - Science, 2017 - science.org
INTRODUCTION Recently, a special class of RNAs has excited researchers and triggered
hundreds of now-published studies. Known as circular RNAs (circRNAs), these RNAs are …

DIANA-LncBase v3: indexing experimentally supported miRNA targets on non-coding transcripts

D Karagkouni, MD Paraskevopoulou… - Nucleic acids …, 2020 - academic.oup.com
Abstract DIANA-LncBase v3. 0 (www. microrna. gr/LncBase) is a reference repository with
experimentally supported miRNA targets on non-coding transcripts. Its third version provides …

Pairing beyond the seed supports microRNA targeting specificity

JP Broughton, MT Lovci, JL Huang, GW Yeo… - Molecular cell, 2016 - cell.com
To identify endogenous miRNA-target sites, we isolated AGO-bound RNAs from
Caenorhabditis elegans by individual-nucleotide resolution crosslinking …

miRNA targeting: growing beyond the seed

LB Chipman, AE Pasquinelli - Trends in genetics, 2019 - cell.com
miRNAs are small RNAs that guide Argonaute proteins to specific target mRNAs to repress
their translation and stability. Canonically, miRNA targeting is reliant on base pairing of the …

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease

H Walgrave, S Balusu, S Snoeck, EV Eynden… - Cell Stem Cell, 2021 - cell.com
Neural stem cells residing in the hippocampal neurogenic niche sustain lifelong
neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally …

Global mapping of small RNA-target interactions in bacteria

S Melamed, A Peer, R Faigenbaum-Romm, YE Gatt… - Molecular cell, 2016 - cell.com
Small RNAs (sRNAs) associated with the RNA chaperon protein Hfq are key
posttranscriptional regulators of gene expression in bacteria. Deciphering the sRNA-target …