A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis

R Nakamura, K Misawa, G Tohnai, M Nakatochi… - Communications …, 2020 - nature.com
Amyotrophic lateral sclerosis (ALS) is a devastating progressive motor neuron disease that
affects people of all ethnicities. Approximately 90% of ALS cases are sporadic and thought …

Challenging the utility of polygenic scores for social science: Environmental confounding, downward causation, and unknown biology

CH Burt - Behavioral and brain sciences, 2023 - cambridge.org
The sociogenomics revolution is upon us, we are told. Whether revolutionary or not,
sociogenomics is poised to flourish given the ease of incorporating polygenic scores (or …

Meta-analyses of genome-wide association studies for postpartum depression

J Guintivano, EM Byrne, J Kiewa… - American Journal of …, 2023 - Am Psychiatric Assoc
Objective: Postpartum depression (PPD) is a common subtype of major depressive disorder
(MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors …

[HTML][HTML] Taking an antiracist posture in scientific publications in human genetics and genomics

KB Brothers, RL Bennett, MK Cho - Genetics in Medicine, 2021 - Elsevier
From its earliest days, the field of human genetics has had a complex, and at times troubling,
connection with racist ideologies. Although the modern field of human genetics and …

Genome-wide association studies of schizophrenia and bipolar disorder in a diverse cohort of US veterans

TB Bigdeli, AH Fanous, Y Li, N Rajeevan… - Schizophrenia …, 2021 - academic.oup.com
Background Schizophrenia (SCZ) and bipolar disorder (BIP) are debilitating
neuropsychiatric disorders, collectively affecting 2% of the world's population. Recognizing …

Don't ignore genetic data from minority populations

C Ben-Eghan, R Sun, JS Hleap, A Diaz-Papkovich… - Nature, 2020 - nature.com
Don’t ignore genetic data from minority populations Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Examining the shared etiology of psychopathology with genome-wide association studies

TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …

Importance of diversity in precision medicine: Generalizability of genetic associations across ancestry groups toward better identification of disease susceptibility …

LA Cruz, JN Cooke Bailey… - Annual review of …, 2023 - annualreviews.org
Genome-wide association studies (GWAS) revolutionized our understanding of common
genetic variation and its impact on common human disease and traits. Developed and …

The legacy of the human genome project

JE Rood, A Regev - Science, 2021 - science.org
Twenty years after the publication of its first draft sequence, the Human Genome Project
(HGP) has had a profound effect on biomedical research—at the bench, on the computer …

Towards a global view of multiple sclerosis genetics

BM Jacobs, M Peter, G Giovannoni, AJ Noyce… - Nature Reviews …, 2022 - nature.com
Multiple sclerosis (MS) is a neuroimmunological disorder of the CNS with a strong heritable
component. The genetic architecture of MS susceptibility is well understood in populations of …