[HTML][HTML] Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition
The characterization of germline genetic variation affecting cancer risk, known as cancer
predisposition, is fundamental to preventive and personalized medicine. Studies of genetic …
predisposition, is fundamental to preventive and personalized medicine. Studies of genetic …
Genetic architecture of dilated cardiomyopathy in individuals of African and European ancestry
E Jordan, DD Kinnamon, GJ Haas, M Hofmeyer… - JAMA, 2023 - jamanetwork.com
Importance Black patients with dilated cardiomyopathy (DCM) have increased familial risk
and worse outcomes than White patients, but most DCM genetic data are from White …
and worse outcomes than White patients, but most DCM genetic data are from White …
Genetic similarity versus genetic ancestry groups as sample descriptors in human genetics
G Coop - arXiv preprint arXiv:2207.11595, 2022 - arxiv.org
A common sample descriptor in human genomics studies is that of'genetic ancestry group',
with terms such as' European genetic ancestry'or'East Asian genetic ancestry'frequently …
with terms such as' European genetic ancestry'or'East Asian genetic ancestry'frequently …
[HTML][HTML] An ensemble penalized regression method for multi-ancestry polygenic risk prediction
Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve
the prediction of complex traits and diseases. However, most existing PRS are primarily …
the prediction of complex traits and diseases. However, most existing PRS are primarily …
Companion diagnostics: state of the art and new regulations
V Valla, S Alzabin, A Koukoura, A Lewis… - Biomarker …, 2021 - journals.sagepub.com
Companion diagnostics (CDx) hail promise of improving the drug development process and
precision medicine. However, there are various challenges involved in the clinical …
precision medicine. However, there are various challenges involved in the clinical …
Heterogeneity and polygenicity in psychiatric disorders: a genome-wide perspective
Genome-wide association studies (GWAS) have been performed for many psychiatric
disorders and revealed a complex polygenic architecture linking mental and physical health …
disorders and revealed a complex polygenic architecture linking mental and physical health …
[HTML][HTML] Polygenic scores in psychiatry: on the road from discovery to implementation
The hypothesis that multiple genetic variants contribute to psychiatric disorders was first
proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic …
proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic …
[HTML][HTML] Shared genetic architectures of educational attainment in East Asian and European populations
Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive
ability, is associated with various health and social outcomes. Previous genome-wide …
ability, is associated with various health and social outcomes. Previous genome-wide …
Human genetic admixture through the lens of population genomics
Over the past 50 years, geneticists have made great strides in understanding how our
species' evolutionary history gave rise to current patterns of human genetic diversity …
species' evolutionary history gave rise to current patterns of human genetic diversity …
[HTML][HTML] Gene-environment correlations and genetic confounding underlying the association between media use and mental health
The increase in online media use and mental health problems have prompted investigations
into their association, although most literature is focussed on deleterious effects. We …
into their association, although most literature is focussed on deleterious effects. We …