[HTML][HTML] Common genetic risk variants identified in the SPARK cohort support DDHD2 as a candidate risk gene for autism
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder. Large
genetically informative cohorts of individuals with ASD have led to the identification of a …
genetically informative cohorts of individuals with ASD have led to the identification of a …
Genetic contributions to bipolar disorder: current status and future directions
KS O'Connell, BJ Coombes - Psychological Medicine, 2021 - cambridge.org
Bipolar disorder (BD) is a highly heritable mental disorder and is estimated to affect about 50
million people worldwide. Our understanding of the genetic etiology of BD has greatly …
million people worldwide. Our understanding of the genetic etiology of BD has greatly …
Ten challenges for clinical translation in psychiatric genetics
Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …
underlying psychiatric disorders and provided important biological insights into disease …
Emerging applications of machine learning in genomic medicine and healthcare
The integration of artificial intelligence technologies has propelled the progress of clinical
and genomic medicine in recent years. The significant increase in computing power has …
and genomic medicine in recent years. The significant increase in computing power has …
[PDF][PDF] Taiwan Biobank: A rich biomedical research database of the Taiwanese population
Summary The Taiwan Biobank (TWB) is an ongoing prospective study of> 150,000
individuals aged 20–70 in Taiwan. A comprehensive list of phenotypes was collected for …
individuals aged 20–70 in Taiwan. A comprehensive list of phenotypes was collected for …
A systematic review and analysis of the use of polygenic scores in pharmacogenomics
D Johnson, MKAP Wilke, SM Lyle… - Clinical …, 2022 - Wiley Online Library
Polygenic scores (PGSs) have emerged as promising tools for complex trait risk prediction.
The application of these scores to pharmacogenomics provides new opportunities to …
The application of these scores to pharmacogenomics provides new opportunities to …
Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology
Our capacity to measure diverse aspects of human biology has developed rapidly in the past
decades, but the rate at which these techniques have generated insights into the biological …
decades, but the rate at which these techniques have generated insights into the biological …
[HTML][HTML] Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases
T Kiiskinen, P Helkkula, K Krebs, J Karjalainen… - Nature medicine, 2023 - nature.com
Little is known about the genetic determinants of medication use in preventing
cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow …
cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow …
[HTML][HTML] Open problems in human trait genetics
Genetic studies of human traits have revolutionized our understanding of the variation
between individuals, and yet, the genetics of most traits is still poorly understood. In this …
between individuals, and yet, the genetics of most traits is still poorly understood. In this …
[HTML][HTML] Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer's disease
Background Despite being twice as likely to get Alzheimer's disease (AD), African
Americans have been grossly underrepresented in AD research. While emerging evidence …
Americans have been grossly underrepresented in AD research. While emerging evidence …