The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms
Understanding and facilitating healthy aging has become a major goal in medical research
and it is becoming increasingly acknowledged that there is a need for understanding the …
and it is becoming increasingly acknowledged that there is a need for understanding the …
Aging promotes metabolic dysfunction-associated steatotic liver disease by inducing ferroptotic stress
Susceptibility to the biological consequences of aging varies among organs and individuals.
We analyzed hepatocyte transcriptomes of healthy young and aged male mice to generate …
We analyzed hepatocyte transcriptomes of healthy young and aged male mice to generate …
Podocyte Ercc1 is indispensable for glomerular integrity
EY Hama, R Nakamichi, A Hishikawa, M Kihara… - Biochemical and …, 2024 - Elsevier
As life expectancy continues to increase, age-related kidney diseases are becoming more
prevalent. Chronic kidney disease (CKD) is not only a consequence of aging but also a …
prevalent. Chronic kidney disease (CKD) is not only a consequence of aging but also a …
[HTML][HTML] Endogenous retroviruses in multiple sclerosis: a network-based etiopathogenic model
S Censi, RM Costantini, A Granzotto… - Ageing Research …, 2024 - Elsevier
The present perspective article proposes an etiopathological model for multiple sclerosis
pathogenesis and progression associated with the activation of human endogenous …
pathogenesis and progression associated with the activation of human endogenous …
Prior‐guided individualized thalamic parcellation based on local diffusion characteristics
Comprising numerous subnuclei, the thalamus intricately interconnects the cortex and
subcortex, orchestrating various facets of brain functions. Extracting personalized …
subcortex, orchestrating various facets of brain functions. Extracting personalized …
Revolutionizing healthcare: IoMT-enabled digital enhancement via multimodal ADL data fusion
The present research develops a framework to refine the classification of an individual's
activities and recognize wellness associated with their routine. The framework improves the …
activities and recognize wellness associated with their routine. The framework improves the …
Establishing healthy longevity clinics in publicly funded hospitals
Healthy longevity medicine integrates geroscience and other disciplines into clinical
settings, aiming to optimize health throughout one's lifespan. Multiple factors have led to …
settings, aiming to optimize health throughout one's lifespan. Multiple factors have led to …
Dissecting unique and common variance across body and brain health indicators using age prediction
Ageing is a heterogeneous multisystem process involving different rates of decline in
physiological integrity across biological systems. The current study dissects the unique and …
physiological integrity across biological systems. The current study dissects the unique and …
Predicting exacerbation of renal function by DNA methylation clock and DNA damage of urinary shedding cells: a pilot study
A Hishikawa, ES Nishimura, N Yoshimoto… - Scientific reports, 2024 - nature.com
Recent reports have shown the feasibility of measuring biological age from DNA methylation
levels in blood cells from specific regions identified by machine learning, collectively known …
levels in blood cells from specific regions identified by machine learning, collectively known …
Plasma proteins as potential biomarkers of aging of single tissue and cell type
D Okada - Biogerontology, 2024 - Springer
Plasma proteins serve as biomarkers of aging and various age-related diseases. While a
number of plasma proteins have been identified that increase or decrease with age, the …
number of plasma proteins have been identified that increase or decrease with age, the …