Lifestyles and their relative contribution to biological aging across multiple organ systems: change analysis from the China Multi-Ethnic Cohort Study
Y Zhang, D Tang, N Zhang, Y Xiang, Y Hu, W Qian… - medRxiv, 2024 - medrxiv.org
Background Biological aging exhibits heterogeneity across multi organ systems. However, it
remains unclear how is lifestyle associated with overall and organ-specific aging and which …
remains unclear how is lifestyle associated with overall and organ-specific aging and which …
Revolutionizing the Life Sciences by Developing a Holographic Digital Mannequin
B Cong, XA Liu, S Zhang, Z Ni, L Wang - Engineering, 2023 - ui.adsabs.harvard.edu
Life processes, including high intelligence, self-organization, and homeostasis, are
characterized by the biological organism in the form of self-renewal, self-replication and self …
characterized by the biological organism in the form of self-renewal, self-replication and self …
Rate of brain aging associates with future executive function in Asian children and older adults
Brain age has emerged as a powerful tool to understand neuroanatomical aging and its link
to health outcomes like cognition. However, most brain age models are trained and tested …
to health outcomes like cognition. However, most brain age models are trained and tested …
Ageing Biomarkers Derived From Retinal Imaging: A Scoping Review
Abstract Background/Aims The emerging concept of retinal age, a biomarker derived from
retinal images, holds promise in estimating biological age. The retinal age gap (RAG) …
retinal images, holds promise in estimating biological age. The retinal age gap (RAG) …
Lung function trajectories from school age to adulthood and their relationship with markers of cardiovascular disease risk
Rationale Lung function in early adulthood is associated with subsequent adverse health
outcomes. Objectives To ascertain whether stable and reproducible lung function …
outcomes. Objectives To ascertain whether stable and reproducible lung function …
Plasma proteomics in the UK Biobank reveals youthful brains and immune systems promote healthspan and longevity
Organ-derived plasma protein signatures derived from aptamer protein arrays track organ-
specific aging, disease, and mortality in humans, but the robustness and clinical utility of …
specific aging, disease, and mortality in humans, but the robustness and clinical utility of …
Organ specificity and commonality of epigenetic aging in low-and high-running capacity rats
Background: Epigenetic drift, which are gradual age-related changes in DNA methylation
patterns, plays a significant role in aging and age-related diseases. However, the …
patterns, plays a significant role in aging and age-related diseases. However, the …
Extracellular vesicles propagate aging in COPD airway epithelial cells by transfer of microRNA-34a
Rationale: Chronic obstructive pulmonary disease (COPD) is associated with the
acceleration of lung aging, demonstrated by the accumulation of senescent cells in lung …
acceleration of lung aging, demonstrated by the accumulation of senescent cells in lung …
A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging
S Libert, A Chekholko, C Kenyon - bioRxiv, 2022 - biorxiv.org
Why people age at different rates is a fundamental, unsolved problem in biology. We created
a model that predicts an individual's age from physiological traits that change with age in the …
a model that predicts an individual's age from physiological traits that change with age in the …
Inferring Multi-Organ Genetic Causal Connections using Imaging and Clinical Data through Mendelian Randomization
Deciphering the complex causal relationships between multiple organs and major clinical
outcomes and the causal interplay among multiple organs remains a significant challenge …
outcomes and the causal interplay among multiple organs remains a significant challenge …