Development of regenerative therapeutic strategies to reverse the progression of advanced
heart failure is one of the most urgent clinical needs of this century. Insights gained from …

In contrast to lower vertebrates, the mammalian heart has a very limited regenerative
capacity. Cardiomyocytes, lost after ischemia, are replaced by fibroblasts. Although the …

The epicardium encapsulates the heart and functions as a source of multipotent progenitor
cells and paracrine factors essential for cardiac development and repair. Injury of the adult …

In the adult, tissue repair after injury is generally compromised by fibrosis, which maintains
tissue integrity with scar formation but does not restore normal architecture and function. The …

Coronary artery disease causes acute myocardial infarction and heart failure. Identifying
coronary vascular progenitors and their developmental program could inspire novel …

Aims It is a dogma of cardiovascular pathophysiology that the increased cardiac mass in
response to increased workload is produced by the hypertrophy of the pre-existing …

Stem cells have the potential to differentiate into cardiovascular cell lineages and to
stimulate tissue regeneration in a paracrine/autocrine manner; thus, they have been …

The disruption in blood supply due to myocardial infarction is a critical determinant for infarct
size and subsequent deterioration in function. The identification of factors that enhance …

Cardiac regeneration, that is, restoration of the original structure and function in a damaged
heart, differs from tissue repair, in which collagen deposition and scar formation often lead to …

Aims After a myocardial infarction, the adult human heart lacks sufficient regenerative
capacity to restore lost tissue, leading to heart failure progression. Finding novel ways to …