Introduction: Thymosin β4, a low molecular weight, naturally-occurring peptide plays a vital
role in the repair and regeneration of injured cells and tissues. After injury, thymosin β4, is …

Conductive cardiac patches have been proven to promote angiogenesis in infarcted
myocardium; however, their conductive integrity, elasticity, and vascularization potential …

Myocardial infarction (MI), caused by coronary heart disease (CHD), remains one of the
most common causes of death in the United States. Over the last few decades, scientists …

The epicardium, the tissue layer covering the cardiac muscle (myocardium), develops from
the proepicardium, a mass of coelomic progenitors located at the venous pole of the …

The overall clinical cardiac regeneration experience suggests that stem cell therapy can be
safely performed, but it also underlines the need for reproducible results for their effective …

From historical studies of developing chick hearts to recent advances in regenerative injury
models, the epicardium has arisen as a key player in heart genesis and repair. The …

During embryonic heart development, the transcription factors Tcf21, Wt1, and Tbx18
regulate activation and differentiation of epicardium-derived cells, including fibroblast …

Over the past two decades, several populations of cardiac stem cells have been described
in the adult mammalian heart. For the most part, however, their lineage origins and in vivo …

Myocardial infarction (MI) is one of the leading causes of morbidity and mortality world-wide.
Whether endogenous repair and regenerative ability could be augmented by drug …

Adrenal glands and gonads share a common primordium (AGP), but the molecular events
driving differentiation are poorly understood. Here we demonstrate that the Wilms tumor …