Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …

The immune system is highly complex and distributed throughout an organism, with
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …

Most signals in genome-wide association studies (GWAS) of complex traits point to
noncoding genetic variants with putative gene regulatory effects. However, currently …

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Systemic lupus erythematosus (SLE) is a severe chronic systemic autoimmune disease
caused by complicated interactions among genetic, epigenetic, and immunological factors …

Understanding functional effects of genetic variants is one of the key challenges in human
genetics, as much of disease-associated variation is located in non-coding regions with …

Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …

The identification of disease-causing genes is critical for mechanistic understanding of
disease etiology and clinical manipulation in disease prevention and treatment. Yet the …

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is
widely assumed that such alleles exert small regulatory effects on the expression of cis …

Using latent variables in gene expression data can help correct unobserved confounders
and increase statistical power for expression quantitative trait Loci (eQTL) detection. The …