Wet granulation is a very important unit operation that finds applications in many industries
mainly pharmaceutical and chemical industries. Various granulation technologies in batch …

The manufacturing of pharmaceutical dosage forms, which has traditionally been a batch-
wise process, is now also transformed into a series of continuous operations. Some …

Continuous manufacturing has attracted increasing research attention in the pharmaceutical
industry within the last decade. Based on the extensive experimental studies, numerous …

It is desirable for a pharmaceutical final dosage form to be manufactured through a quality
by design (QbD)-based approach rather than a quality by testing (QbT) approach. An …

A novel manufacturing strategy based on continuous processing integrated with
online/inline monitoring tools coupled with an advanced control system is highly desired for …

The objective of this work is to present a review of computational tools and models for
pharmaceutical processes, specifically those for the continuous manufacture of solid dosage …

In this study, a novel mechanistic model for a wet granulation process is presented,
combining the techniques of population balance modeling and discrete element methods to …

Two-dimensional population balance model (PBM) is developed in order to model
pharmaceutical granules formation in a twin-screw wet granulator. Granule size and liquid …

The pharmaceutical industry currently faces economic and regulatory challenges associated
with process development. Process modeling tools can play a role in developing robust and …

Wet granulation is a complex particle design process often operated inefficiently in industrial
applications. Enhanced process understanding is required to facilitate design, control, and …