Inflammation and autophagy are cellular defense mechanisms. When these processes are
deregulated (deficient or overactivated) they produce pathologic effects, such as oxidative …

Acute pancreatitis is a common clinical condition. It is a disease of variable severity in which
some patients experience mild, self-limited attacks while others manifest a severe, highly …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a high degree of
inflammation and profound immune suppression. Here we identify Yes-associated protein …

Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of
systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology …

We have investigated in detail the role of intra-organelle Ca 2+ content during induction of
apoptosis by the oxidant menadione while changing and monitoring the Ca 2+ load of …

Mechanisms of cell death in pancreatitis remain unknown. Parenchymal necrosis is a major
complication of pancreatitis; also, the severity of experimental pancreatitis correlates directly …

Cell death and inflammation are key pathologic responses of acute pancreatitis (AP), the
leading cause of hospital admissions for gastrointestinal disorders. It is becoming …

Abstract The plasma membrane Ca 2+-ATPase (PMCA) is a ubiquitously expressed, ATP-
driven Ca 2+ pump that is critical for maintaining low resting cytosolic Ca 2+([Ca 2+] i) in all …

Tumor necrosis factor (TNF)-α is a pleiotropic cytokine that exerts host-damaging effects in
different autoimmune and inflammatory diseases. It is a key regulator of other …

Numerous plants have been documented to contain phenolic compounds. Thymol is one
among these phenolic compounds that possess a repertoire of pharmacological activities …