Two recent seminal works have untangled the intricate role of tumor-associated senescent
cells in cancer progression, or regression, by guiding our immune system against cancer …

Senescent cancer cells alter their microenvironment through secretion of pro-inflammatory
cytokines and chemokines called the senescence-associated secretory phenotype (SASP) …

Introduction Senescence refers to a state of permanent cell growth arrest and is regarded as
a tumor suppressive mechanism, whereas accumulative evidence demonstrate that …

The initial excitement generated more than two decades ago by the discovery of drugs
targeting fatty acid synthase (FASN)‐catalyzed de novo lipogenesis for cancer therapy was …

Cellular senescence accumulates with age and has been shown to impact numerous
physiological and pathological processes, including immune function. The role of cellular …

Simple Summary Lamins are a family of nuclear proteins consisting of A-and B-type lamins.
As they are integral parts of the nuclear lamina, it was generally accepted that they have …

Background Radiotherapy (RT) destroys cancer cells and activates the immune system
while suppressing the immunity of tumor-associated tissues, including the tumor …

There is a significant overlap between HIV infection and substance-use disorders.
Dopamine (DA) is the most abundantly upregulated neurotransmitter in methamphetamine …

The timing and location of senescent cells in vivo is a leading candidate explanation for
human aging. A rapidly developing scientific field with the potential to slow the aging …

Senolysis, the elimination of senescent cells (SNCs), is a novel therapeutic concept for the
treatment of aging and agerelated diseases that has scored a first success in the clinic for …