[HTML][HTML] Dopamine and levodopa prodrugs for the treatment of Parkinson's disease

F Haddad, M Sawalha, Y Khawaja, A Najjar… - Molecules, 2017 - mdpi.com
Background: Parkinson's disease is an aggressive and progressive neurodegenerative
disorder that depletes dopamine (DA) in the central nervous system. Dopamine replacement …

Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death

JS Bains, CA Shaw - Brain research reviews, 1997 - Elsevier
Oxidative stress has been implicated in both normal aging and in various
neurodegenerative disorders and may be a common mechanism underlying various forms …

Serotonergic modulation of the activity of mesencephalic dopaminergic systems: therapeutic implications

P De Deurwaerdère, G Di Giovanni - Progress in neurobiology, 2017 - Elsevier
Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

Recognition-mediated activation of therapeutic gold nanoparticles inside living cells

C Kim, SS Agasti, Z Zhu, L Isaacs, VM Rotello - Nature chemistry, 2010 - nature.com
Supramolecular chemistry provides a versatile tool for the organization of molecular systems
into functional structures and the actuation of these assemblies for applications through the …

Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra

CC Ferrari, MCP Godoy, R Tarelli, M Chertoff… - Neurobiology of …, 2006 - Elsevier
The functional role of the long-lasting inflammation found in the substantia nigra (SN) of
Parkinson's disease (PD) patients and animal models is unclear. Proinflammatory cytokines …

Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson's disease

PJ Richardson, H Kase, PG Jenner - Trends in pharmacological sciences, 1997 - cell.com
There is now good reason to believe that blockade of the adenosine A 2A receptor could be
of value in the treatment of Parkinson's disease. Peter J. Richardson, Hiroshi Kase and Peter …

Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks

M Alkondon, EFR Pereira, HM Eisenberg… - Journal of …, 2000 - Soc Neuroscience
Cholinergic control of the activity of human cerebral cortical circuits has long been thought to
be accounted for by the interaction of acetylcholine (ACh) with muscarinic receptors. Here …

Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies

V Di Matteo, G Di Giovanni, M Pierucci… - Progress in brain …, 2008 - Elsevier
In this review, the functional interactions between serotonin (5-HT) and dopamine (DA)
neuronal systems are discussed with the focus on microdialysis studies in the rodent brain …

Role of serotonin in central dopamine dysfunction

G Di Giovanni, E Esposito… - CNS neuroscience & …, 2010 - Wiley Online Library
The interaction between serotonin (5‐HT) and dopamine (DA)‐containing neurons in the
brain is a research topic that has raised the interest of many scientists working in the field of …

[HTML][HTML] Mechanistic insights, treatment paradigms, and clinical progress in neurological disorders: current and future prospects

S Alkahtani, NS Al-Johani, S Alarifi - International Journal of Molecular …, 2023 - mdpi.com
Neurodegenerative diseases (NDs) are a major cause of disability and are related to brain
development. The neurological signs of brain lesions can vary from mild clinical shortfalls to …