In 1878, Billroth discovered that tumor cells invest themselves in a fibrin thrombus, and he
hypothesized that fibrin promotes tumor growth and invasion. Since then, many observations …

The fibrinolytic system, more appropriately referred to as the plasminogen activator system,
controls not only the intravascular fibrin deposition but also participates in a wide variety of …

Components of the plasminogen-plasmin system participate in a wide variety of physiologic
and pathologic processes, including tumor growth, invasion and metastasis, through their …

The chick-embryo model has been an important tool to study tumor growth, metastasis, and
angiogenesis. However, an imageable model with a genetic fluorescent tag in the growing …

The blood coagulation mechanism in general and the plasminogen system in particular
contribute to malignant growth and dissemination in complex ways. This article reviews the …

Platelets play an essential role in hemostasis, the arrest of bleeding. In response to vascular
injury, platelets become adherent and undergo activation and aggregation. The formation of …