Deep immunoglobulin repertoire sequencing depicts a comprehensive atlas of spike-specific antibody lineages shared among COVID-19 convalescents

Q Yan, Y Zhang, R Hou, W Pan, H Liang… - Emerging Microbes & …, 2024 - Taylor & Francis
Neutralizing antibodies are a key component in protective humoral immunity against SARS-
CoV-2. Currently, available technologies cannot track epitope-specific antibodies in global …

The characteristics of BCR‐CDR3 repertoire in COVID‐19 patients and SARS‐CoV‐2 vaccinated volunteers

J Xiao, Y Luo, Y Li, X Yao - Journal of Medical Virology, 2024 - Wiley Online Library
The global COVID‐19 pandemic has caused more than 1 billion infections, and numerous
SARS‐CoV‐2 vaccines developed rapidly have been administered over 10 billion doses …

Fast-Track Discovery of SARS-CoV-2-Neutralizing Antibodies from Human B Cells by Direct Functional Screening

M Hillenbrand, C Esslinger, J Seidenberg, M Weber… - Viruses, 2024 - mdpi.com
As the COVID-19 pandemic revealed, rapid development of vaccines and therapeutic
antibodies are crucial to guarantee a quick return to the status quo of society. In early 2020 …

Structure-Based Optimization of One Neutralizing Antibody against SARS-CoV-2 Variants Bearing the L452R Mutation

Y Chen, J Zha, S Xu, J Shao, X Liu, D Li, X Zhang - Viruses, 2024 - mdpi.com
Neutralizing antibodies (nAbs) play an important role against SARS-CoV-2 infections.
Previously, we have reported one potent receptor binding domain (RBD)-binding nAb Ab08 …

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

Y Lu, Q Yang, T Ran, G Zhang, W Li, P Zhou, J Tang… - bioRxiv, 2024 - biorxiv.org
The RNA-dependent RNA polymerase (RdRp), 3C-like protease (3CLpro), and papain-like
protease (PLpro) are pivotal components in the viral life cycle of SARS-CoV-2, presenting as …