Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment

J Chen, C Xu, K Yang, R Gao, Y Cao, L Liang… - Nature …, 2023 - nature.com
Ischemia reperfusion injury (IRI) is a common cause of acute kidney injury (AKI). The role of
N6-methyladenosine (m6A) modification in AKI remains unclear. Here, we characterize the …

Experimental models of acute kidney injury for translational research

NA Hukriede, DE Soranno, V Sander… - Nature Reviews …, 2022 - nature.com
Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen

Z Li, C Kuppe, S Ziegler, M Cheng, N Kabgani… - Nature …, 2021 - nature.com
A major drawback of single-cell ATAC-seq (scATAC-seq) is its sparsity, ie, open chromatin
regions with no reads due to loss of DNA material during the scATAC-seq protocol. Here, we …

Anatomical structures, cell types and biomarkers of the Human Reference Atlas

K Börner, SA Teichmann, EM Quardokus, JC Gee… - Nature cell …, 2021 - nature.com
Abstract The Human Reference Atlas (HRA) aims to map all of the cells of the human body
to advance biomedical research and clinical practice. This Perspective presents …

Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition

L Xu, J Guo, DG Moledina, LG Cantley - Nature communications, 2022 - nature.com
Incomplete repair after acute kidney injury can lead to development of chronic kidney
disease. To define the mechanism of this response, we compared mice subjected to …

Spatially resolved transcriptomic analysis of acute kidney injury in a female murine model

EE Dixon, H Wu, Y Muto, PC Wilson… - Journal of the …, 2022 - journals.lww.com
Background Single-cell sequencing technologies have advanced our understanding of
kidney biology and disease, but the loss of spatial information in these datasets hinders our …

Cellular recovery after prolonged warm ischaemia of the whole body

D Andrijevic, Z Vrselja, T Lysyy, S Zhang, M Skarica… - Nature, 2022 - nature.com
After cessation of blood flow or similar ischaemic exposures, deleterious molecular
cascades commence in mammalian cells, eventually leading to their death,. Yet with …

The mesangial cell—the glomerular stromal cell

S Avraham, B Korin, JJ Chung, L Oxburgh… - Nature Reviews …, 2021 - nature.com
Mesangial cells are stromal cells that are important for kidney glomerular homeostasis and
the glomerular response to injury. A growing body of evidence demonstrates that …

Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease

L De Chiara, C Conte, R Semeraro… - Nature …, 2022 - nature.com
Acute kidney injury (AKI) is frequent, often fatal and, for lack of specific therapies, can leave
survivors with chronic kidney disease (CKD). We characterize the distribution of tubular cells …

Mapping the human kidney using single-cell genomics

F Schreibing, R Kramann - Nature Reviews Nephrology, 2022 - nature.com
The field of single-cell genomics and spatial technologies is rapidly evolving and has
already provided unprecedented insights into complex tissues. Major advances have been …