NA Hukriede, DE Soranno, V Sander… - Nature Reviews …, 2022 - nature.com
Preclinical models of human disease provide powerful tools for therapeutic discovery but have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …
Z Li, C Kuppe, S Ziegler, M Cheng, N Kabgani… - Nature …, 2021 - nature.com
A major drawback of single-cell ATAC-seq (scATAC-seq) is its sparsity, ie, open chromatin regions with no reads due to loss of DNA material during the scATAC-seq protocol. Here, we …
Abstract The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents …
L Xu, J Guo, DG Moledina, LG Cantley - Nature communications, 2022 - nature.com
Incomplete repair after acute kidney injury can lead to development of chronic kidney disease. To define the mechanism of this response, we compared mice subjected to …
EE Dixon, H Wu, Y Muto, PC Wilson… - Journal of the …, 2022 - journals.lww.com
Background Single-cell sequencing technologies have advanced our understanding of kidney biology and disease, but the loss of spatial information in these datasets hinders our …
After cessation of blood flow or similar ischaemic exposures, deleterious molecular cascades commence in mammalian cells, eventually leading to their death,. Yet with …
S Avraham, B Korin, JJ Chung, L Oxburgh… - Nature Reviews …, 2021 - nature.com
Mesangial cells are stromal cells that are important for kidney glomerular homeostasis and the glomerular response to injury. A growing body of evidence demonstrates that …
L De Chiara, C Conte, R Semeraro… - Nature …, 2022 - nature.com
Acute kidney injury (AKI) is frequent, often fatal and, for lack of specific therapies, can leave survivors with chronic kidney disease (CKD). We characterize the distribution of tubular cells …
F Schreibing, R Kramann - Nature Reviews Nephrology, 2022 - nature.com
The field of single-cell genomics and spatial technologies is rapidly evolving and has already provided unprecedented insights into complex tissues. Major advances have been …