[HTML][HTML] Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury

J Klocke, SJ Kim, CM Skopnik, C Hinze… - Kidney International, 2022 - Elsevier
Acute kidney injury (AKI) is a major health issue, the outcome of which depends primarily on
damage and reparative processes of tubular epithelial cells. Mechanisms underlying AKI …

Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

S Rayego-Mateos, S Campillo… - Clinical …, 2021 - portlandpress.com
Chronic kidney disease (CKD) is characterized by pathological accumulation of extracellular
matrix (ECM) proteins in renal structures. Tubulointerstitial fibrosis is observed in glomerular …

New aspects of kidney fibrosis–from mechanisms of injury to modulation of disease

MJ Moeller, R Kramann, T Lammers, B Hoppe… - Frontiers in …, 2022 - frontiersin.org
Organ fibrogenesis is characterized by a common pathophysiological final pathway
independent of the underlying progressive disease of the respective organ. This makes it …

Loss of proximal tubular transcription factor Krüppel-like factor 15 exacerbates kidney injury through loss of fatty acid oxidation

SE Piret, AA Attallah, X Gu, Y Guo, NA Gujarati… - Kidney international, 2021 - Elsevier
Loss of fatty acid β-oxidation (FAO) in the proximal tubule is a critical mediator of acute
kidney injury and eventual fibrosis. However, transcriptional mediators of FAO in proximal …

Predicting proximal tubule failed repair drivers through regularized regression analysis of single cell multiomic sequencing

N Ledru, PC Wilson, Y Muto, Y Yoshimura, H Wu… - Nature …, 2024 - nature.com
Renal proximal tubule epithelial cells have considerable intrinsic repair capacity following
injury. However, a fraction of injured proximal tubule cells fails to undergo normal repair and …

[HTML][HTML] Kidney repair and regeneration: perspectives of the NIDDK (Re) Building a Kidney consortium

BA Naved, JV Bonventre, JA Hubbell, NA Hukriede… - Kidney international, 2022 - Elsevier
Acute kidney injury impacts∼ 13.3 million individuals and causes∼ 1.7 million deaths per
year globally. Numerous injury pathways contribute to acute kidney injury, including cell …

Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis

B Wang, L Yang, L Yang, Y Liang, F Guo… - Acta Pharmacologica …, 2024 - nature.com
Kidney fibrosis is the hallmark of chronic kidney disease (CKD) progression, whereas no
effective anti-fibrotic therapies exist. Recent evidence has shown that tubular ferroptosis …

[HTML][HTML] Single‐cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium

PM Kirkwood, DA Gibson, JR Smith… - The FASEB …, 2021 - ncbi.nlm.nih.gov
The endometrium is a dynamic tissue that exhibits remarkable resilience to repeated
episodes of differentiation, breakdown, regeneration, and remodeling. Endometrial …

Decreased renal gluconeogenesis is a hallmark of chronic kidney disease

T Verissimo, A Faivre, A Rinaldi… - Journal of the …, 2022 - journals.lww.com
Methods We used data on the renal gluconeogenic pathway from more than 200 renal
biopsies performed on CKD patients and from 43 kidney allograft patients, and studied three …

[HTML][HTML] Impaired fatty acid metabolism perpetuates lipotoxicity along the transition to chronic kidney injury

A Rinaldi, H Lazareth, V Poindessous, I Nemazanyy… - JCI insight, 2022 - ncbi.nlm.nih.gov
Energy metabolism failure in proximal tubule cells (PTCs) is a hallmark of chronic kidney
injury. We combined transcriptomic, metabolomic, and lipidomic approaches in experimental …