Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines

A Sette, S Crotty - Immunological reviews, 2022 - Wiley Online Library
Immunological memory is the basis of protective immunity provided by vaccines and
previous infections. Immunological memory can develop from multiple branches of the …

T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection

DG Augusto, LD Murdolo, DSM Chatzileontiadou… - Nature, 2023 - nature.com
Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2
remain asymptomatic,,–. Although most global efforts have focused on severe illness in …

Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection

MM Painter, TS Johnston, KA Lundgreen… - Nature …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of vaccinated
individuals is increasingly common but rarely results in severe disease, likely due to the …

SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

A Bertoletti, N Le Bert, AT Tan - Immunity, 2022 - cell.com
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …

[HTML][HTML] SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity

JME Lim, AT Tan, N Le Bert, SK Hang… - Journal of Experimental …, 2022 - rupress.org
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+
and CD4+ T cells of broad specificity | Journal of Experimental Medicine | Rockefeller …

Mucosal immune responses to infection and vaccination in the respiratory tract

RC Mettelman, EK Allen, PG Thomas - Immunity, 2022 - cell.com
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …

VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2

M Goncharov, D Bagaev, D Shcherbinin, I Zvyagin… - Nature …, 2022 - nature.com
In 2016, we started a community effort to gather and curate publicly available sequence data
acquired from T cell receptor (TCRs) with defined antigen specificities, as well as …

Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection

F Gao, V Mallajosyula, PS Arunachalam… - Immunity, 2023 - cell.com
T cells are a critical component of the response to SARS-CoV-2, but their kinetics after
infection and vaccination are insufficiently understood. Using" spheromer" peptide-MHC …

SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19

C Cai, Y Gao, S Adamo, O Rivera-Ballesteros… - Science …, 2023 - science.org
T cells are critical for immune protection against severe COVID-19, but it has remained
unclear whether repeated exposure to SARS-CoV-2 antigens delivered in the context of …