[HTML][HTML] Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model
We introduce mvSuSiE, a multi-trait fine-mapping method for identifying putative causal
variants from genetic association data (individual-level or summary data). mvSuSiE learns …
variants from genetic association data (individual-level or summary data). mvSuSiE learns …
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
X Meng, G Navoly, O Giannakopoulou, DF Levey… - Nature Genetics, 2024 - nature.com
Most genome-wide association studies (GWAS) of major depression (MD) have been
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
[PDF][PDF] Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology
Polygenic risk scores (PRSs) developed from multi-ancestry genome-wide association
studies (GWASs), PRS multi, hold promise for improving PRS accuracy and generalizability …
studies (GWASs), PRS multi, hold promise for improving PRS accuracy and generalizability …
sfkit: a web-based toolkit for secure and federated genomic analysis
S Mendelsohn, D Froelicher, D Loginov… - Nucleic Acids …, 2023 - academic.oup.com
Advances in genomics are increasingly depending upon the ability to analyze large and
diverse genomic data collections, which are often difficult to amass due to privacy concerns …
diverse genomic data collections, which are often difficult to amass due to privacy concerns …
[HTML][HTML] Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases
Genome-wide association studies (GWAS) of human complex traits or diseases often
implicate genetic loci that span hundreds or thousands of genetic variants, many of which …
implicate genetic loci that span hundreds or thousands of genetic variants, many of which …
East Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease
Peptic ulcer disease (PUD) refers to acid-induced injury of the digestive tract, occurring
mainly in the stomach (gastric ulcer (GU)) or duodenum (duodenal ulcer (DU)). In the …
mainly in the stomach (gastric ulcer (GU)) or duodenum (duodenal ulcer (DU)). In the …
A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits using GWAS summary statistics
Genome-wide association studies (GWASs) across thousands of traits have revealed the
pervasive pleiotropy of trait-associated genetic variants. While methods have been …
pervasive pleiotropy of trait-associated genetic variants. While methods have been …
Nuclear genetic control of mtDNA copy number and heteroplasmy in humans
Mitochondrial DNA (mtDNA) is a maternally inherited, high-copy-number genome required
for oxidative phosphorylation. Heteroplasmy refers to the presence of a mixture of mtDNA …
for oxidative phosphorylation. Heteroplasmy refers to the presence of a mixture of mtDNA …
Identification of 27 allele-specific regulatory variants in Parkinson's disease using a massively parallel reporter assay
Genome wide association studies (GWAS) have identified a number of genomic loci that are
associated with Parkinson's disease (PD) risk. However, the majority of these variants lie in …
associated with Parkinson's disease (PD) risk. However, the majority of these variants lie in …
Secure and federated genome-wide association studies for Biobank-scale datasets
H Cho, D Froelicher, J Chen, M Edupalli, A Pyrgelis… - bioRxiv, 2022 - biorxiv.org
Sharing data across multiple institutions for genome-wide association studies (GWAS)
would enable discovery of novel genetic variants linked to health and disease. However …
would enable discovery of novel genetic variants linked to health and disease. However …