Process intensification offers the potential to drastically reduce the energy consumption and
cost of producing chemicals from both bulk and distributed feedstocks. This review article …

Mathematical models can be used as an integral part of the quality by design (QbD) concept
throughout the product lifecycle for variety of purposes, including appointment of the design …

Incorporating (operational) flexibility into process design has been a key approach to cope
with uncertainties. The increasing penetration of renewables and the need for developing …

The purpose of this paper is to provide a summary of the current state of the application of
process systems engineering tools in the pharmaceutical industry. In this paper, we present …

Introduction The identification and graphical representation of process design space are
critical in locating not only feasible but also optimum operating variable ranges and design …

This paper provides an overview of concepts and computational approaches for the
evaluation of feasibility/flexibility and how they can be used for process design and process …

Dealing with uncertainty is one of practical issues in design and operation of heat exchanger
networks (HENs), arising the problem of flexible HEN synthesis. This paper addresses the …

This work presents a comprehensive classification of the different methods and procedures
for integrated synthesis, design and control of chemical processes, based on a wide revision …

Feasibility analysis is a useful technique for evaluating the operability and ultimately the
flexibility of chemical processes. However, it is difficult to solve the feasibility test problem for …

Recent studies on modular and distributed manufacturing have introduced a new angle to
the traditional economies of scale that claim that large plants exhibit better efficiencies and …