Polygenic scores (PGSs) offer the ability to predict genetic risk for complex diseases across
the life course; a key benefit over short-term prediction models. To produce risk estimates …

It is established that there are sex differences in terms of prevalence, age of onset, clinical
manifestations, and response to treatment for a variety of brain disorders, including …

The role of gene-environment (GxE) interaction in disease and complex trait architectures is
widely hypothesized, but currently unknown. Here, we apply three statistical approaches to …

The prevalence of heart failure (HF) subtypes, which are classified by left ventricular ejection
fraction (LVEF), demonstrate significant sex differences. Here, we perform sex-stratified …

Genetic effects can be sex-specific, particularly for traits such as testosterone, a sex
hormone. While sex-stratified analysis provides easily interpretable sex-specific effect size …

Differences in the patterning of genetic sharing and differentiation between groups may
arise from differences in biological pathways, social mechanisms, phenotyping and …

Gender control technologies are promising for enhancing the production efficiency of the
farm animal industry, and preventing sex-linked hereditary diseases in humans. It has been …

In this cohort profile article we describe the lifetime major depressive disorder (MDD)
database that has been established as part of the BIObanks Netherlands Internet …

Background: While sex differences in right heart phenotypes have been observed, the
molecular drivers remain unknown. We used common genetic variation to provide biological …

Background Alcohol consumption behaviors and alcohol use disorder risk and presentation
differ by sex, and these complex traits are associated with blood concentrations of the …