DNA methylation and healthy human aging

MJ Jones, SJ Goodman, MS Kobor - Aging cell, 2015 - Wiley Online Library
The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

Forensic DNA phenotyping: predicting human appearance from crime scene material for investigative purposes

M Kayser - Forensic Science International: Genetics, 2015 - Elsevier
Forensic DNA Phenotyping refers to the prediction of appearance traits of unknown sample
donors, or unknown deceased (missing) persons, directly from biological materials found at …

[HTML][HTML] Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

A Quach, ME Levine, T Tanaka, AT Lu, BH Chen… - Aging (albany …, 2017 - ncbi.nlm.nih.gov
Behavioral and lifestyle factors have been shown to relate to a number of health-related
outcomes, yet there is a need for studies that examine their relationship to molecular aging …

[HTML][HTML] Evaluation of DNA methylation episignatures for diagnosis and phenotype correlations in 42 Mendelian neurodevelopmental disorders

E Aref-Eshghi, J Kerkhof, VP Pedro… - The American Journal of …, 2020 - cell.com
Genetic syndromes frequently present with overlapping clinical features and inconclusive or
ambiguous genetic findings which can confound accurate diagnosis and clinical …

Underlying features of epigenetic aging clocks in vivo and in vitro

Z Liu, D Leung, K Thrush, W Zhao, S Ratliff… - Aging cell, 2020 - Wiley Online Library
Epigenetic clocks, developed using DNA methylation data, have been widely used to
quantify biological aging in multiple tissues/cells. However, many existing epigenetic clocks …

Menopause accelerates biological aging

ME Levine, AT Lu, BH Chen… - Proceedings of the …, 2016 - National Acad Sciences
Although epigenetic processes have been linked to aging and disease in other systems, it is
not yet known whether they relate to reproductive aging. Recently, we developed a highly …

[HTML][HTML] Accounting for cellular heterogeneity is critical in epigenome-wide association studies

AE Jaffe, RA Irizarry - Genome biology, 2014 - Springer
Background Epigenome-wide association studies of human disease and other quantitative
traits are becoming increasingly common. A series of papers reporting age-related changes …

HIV-1 infection accelerates age according to the epigenetic clock

S Horvath, AJ Levine - The Journal of infectious diseases, 2015 - academic.oup.com
Background. Infection with human immunodeficiency virus type 1 (HIV) is associated with
clinical symptoms of accelerated aging, as evidenced by the increased incidence and …

[HTML][HTML] Aging of blood can be tracked by DNA methylation changes at just three CpG sites

CI Weidner, Q Lin, CM Koch, L Eisele, F Beier… - Genome biology, 2014 - Springer
Background Human aging is associated with DNA methylation changes at specific sites in
the genome. These epigenetic modifications may be used to track donor age for forensic …

[HTML][HTML] Heterochromatin: an epigenetic point of view in aging

JH Lee, EW Kim, DL Croteau, VA Bohr - Experimental & molecular …, 2020 - nature.com
Aging is an inevitable process of life. Defined by progressive physiological and functional
loss of tissues and organs, aging increases the risk of mortality for the organism. The aging …