Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation

JAHR Claassen, DHJ Thijssen… - Physiological …, 2021 - journals.physiology.org
Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Neurovascular coupling in humans: physiology, methodological advances and clinical implications

AA Phillips, FHN Chan, MMZ Zheng… - Journal of Cerebral …, 2016 - journals.sagepub.com
Neurovascular coupling reflects the close temporal and regional linkage between neural
activity and cerebral blood flow. Although providing mechanistic insight, our understanding …

Cardiac output and cerebral blood flow: the integrated regulation of brain perfusion in adult humans

L Meng, W Hou, J Chui, R Han, AW Gelb - Anesthesiology, 2015 - pubs.asahq.org
Cerebral blood flow (CBF) is rigorously regulated by various powerful mechanisms to
safeguard the match between cerebral metabolic demand and supply. The question of how …

Lower body negative pressure: physiological effects, applications, and implementation

N Goswami, AP Blaber… - Physiological …, 2019 - journals.physiology.org
This review presents lower body negative pressure (LBNP) as a unique tool to investigate
the physiology of integrated systemic compensatory responses to altered hemodynamic …

Transcranial Doppler ultrasound: a review of the physical principles and major applications in critical care

J Naqvi, KH Yap, G Ahmad… - International journal of …, 2013 - Wiley Online Library
Transcranial Doppler (TCD) is a noninvasive ultrasound (US) study used to measure
cerebral blood flow velocity (CBF‐V) in the major intracranial arteries. It involves use of low …

Cerebral blood flow during exercise: mechanisms of regulation

S Ogoh, PN Ainslie - Journal of applied physiology, 2009 - journals.physiology.org
The response of cerebral vasculature to exercise is different from other peripheral
vasculature; it has a small vascular bed and is strongly regulated by cerebral autoregulation …

Transfer function analysis of dynamic cerebral autoregulation in humans

R Zhang, JH Zuckerman, CA Giller… - American Journal of …, 1998 - journals.physiology.org
To test the hypothesis that spontaneous changes in cerebral blood flow are primarily
induced by changes in arterial pressure and that cerebral autoregulation is a frequency …

MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis

JM Serrador, PA Picot, BK Rutt, JK Shoemaker… - Stroke, 2000 - Am Heart Assoc
Background and Purpose—The relationship between middle cerebral artery (MCA) flow
velocity (CFV) and cerebral blood flow (CBF) is uncertain because of unknown vessel …

Cerebral autoregulation: an overview of current concepts and methodology with special focus on the elderly

AHEA Van Beek, JAHR Claassen… - Journal of Cerebral …, 2008 - journals.sagepub.com
Cerebral autoregulation (CA) refers to the properties of the brain vascular bed to maintain
cerebral perfusion despite changes in blood pressure (BP). Whereas classic studies have …

Assessment of cerebral pressure autoregulation in humans-a review of measurement methods

RB Panerai - Physiological measurement, 1998 - iopscience.iop.org
Assessment of cerebral autoregulation is an important adjunct to measurement of cerebral
blood flow for diagnosis, monitoring or prognosis of cerebrovascular disease. The most …