Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Since the introduction of penicillin, β-lactam antibiotics have been the antimicrobial agents
of choice. Unfortunately, the efficacy of these life-saving antibiotics is significantly threatened …

The ascendancy of metallo-β-lactamases within the clinical sector, while not ubiquitous, has
nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistant …

The simplistic image of the bacterium as an isolated, planktonic, self-cloning automaton is
refuted. We now recognize bacteria as microorganisms of enormous diversity and …

Metallo-β-Lactamases (MBLs) are class B β-lactamases that hydrolyze almost all clinically-
available β-lactam antibiotics. MBLs feature the distinctive αβ/βα sandwich fold of the …

Antibiotic resistance caused by β-lactamase production continues to present a growing
challenge to the efficacy of β-lactams and their role as the most important class of clinically …

In living organisms it is necessary to be able to perform countless hydrolysis reactions
efficiently and, above all, selectively to sustain thousands, maybe even millions, of critical …

ABSTRACT β-Lactamase-mediated resistance is a growing threat to the continued use of β-
lactam antibiotics. The use of the β-lactam-based serine-β-lactamase (SBL) inhibitors …

The use of the three classical β-lactamase inhibitors (clavulanic acid, tazobactam and
sulbactam) in combination with β-lactam antibacterials is currently the most successful …

Pathogenic Gram-negative bacteria resistant to almost all β-lactam antibiotics are a major
public health threat. Zn (II)-dependent or metallo-β-lactamases (MBLs) produced by these …