Influences of polycyclic aromatic hydrocarbon on the epigenome toxicity and its applicability in human health risk assessment

DN Das, N Ravi - Environmental research, 2022 - Elsevier
The existence of polycyclic aromatic hydrocarbons (PAHs) in ambient air is an escalating
concern worldwide because of their ability to cause cancer and induce permanent changes …

CRISPR/Cas system and factors affecting its precision and efficiency

N Javaid, S Choi - Frontiers in cell and developmental biology, 2021 - frontiersin.org
The diverse applications of genetically modified cells and organisms require more precise
and efficient genome-editing tool such as clustered regularly interspaced short palindromic …

The epigenetics of the endocannabinoid system

R Meccariello, A Santoro, S D'Angelo… - International journal of …, 2020 - mdpi.com
The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological
tissues that includes endogenous ligands, receptors, and biosynthetic and hydrolysing …

m6A RNA methylation: ramifications for gene expression and human health

R Karthiya, P Khandelia - Molecular biotechnology, 2020 - Springer
Cellular transcriptomes are frequently adorned by a variety of chemical modification marks,
which in turn have a profound influence on its functioning. Of these modifications, the one …

Epigenetic changes in gastric cancer induction by Helicobacter pylori

B Yousefi, M Mohammadlou… - Journal of cellular …, 2019 - Wiley Online Library
Epigenetic disorder mechanisms are one of the causes of cancer. The most important of
these changes is the DNA methylation, which leads to the spread of Helicobacter pylori and …

[HTML][HTML] Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

A Osipyan, D Chen, FJ Dekker - Drug discovery today, 2021 - Elsevier
Highlights•Macrophage migration inhibitory factor (MIF) plays a crucial role in cancer and
inflammatory diseases.•Epigenetic mechanisms are involved in MIF-mediated …

Mitochondrial dysfunction, neurogenesis, and epigenetics: putative implications for amyotrophic lateral sclerosis neurodegeneration and treatment

ML Calió, E Henriques, A Siena… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive and devastating multifactorial
neurodegenerative disorder. Although the pathogenesis of ALS is still not completely …

The effect of a methyl group on structure and function: Serine vs. threonine glycosylation and phosphorylation

JJ Barchi Jr, CN Strain - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
A variety of glycan structures cover the surface of all cells and are involved in myriad
biological processes, including but not limited to, cell adhesion and communication, protein …

Methylation in HOX Clusters and Its Applications in Cancer Therapy

A Paço, SA de Bessa Garcia, R Freitas - Cells, 2020 - mdpi.com
HOX genes are commonly known for their role in embryonic development, defining the
positional identity of most structures along the anterior–posterior axis. In postembryonic life …

Fast-fed variability: insights into drug delivery, molecular manifestations, and regulatory aspects

N Rangaraj, S Sampathi, V Junnuthula, P Kolimi… - Pharmaceutics, 2022 - mdpi.com
Among various drug administration routes, oral drug delivery is preferred and is considered
patient-friendly; hence, most of the marketed drugs are available as conventional tablets or …