Clinical efficacy of launched JAK inhibitors in rheumatoid arthritis

PC Taylor - Rheumatology, 2019 - academic.oup.com
Tofacitinib and baricitinib are the first orally available, small-molecule inhibitors of Janus
kinase (JAK) enzymes to be approved for the treatment of RA. Tofacitinib is a selective JAK1 …

Host modulation: controlling the inflammation to control the infection

PM Bartold, TE Van Dyke - Periodontology 2000, 2017 - Wiley Online Library
Historically, periodontal disease (gingivitis and periodontitis) has been recognized as being
primarily of bacterial origin. However, recent evidence indicates that while bacteria are …

[HTML][HTML] Gut microbiota in pre-clinical rheumatoid arthritis: From pathogenesis to preventing progression

L Lin, K Zhang, Q Xiong, J Zhang, B Cai, Z Huang… - Journal of …, 2023 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive
polyarthritis that leads to cartilage and bone damage. Pre-clinical RA is a prolonged state …

Assessment of a deep learning model based on electronic health record data to forecast clinical outcomes in patients with rheumatoid arthritis

B Norgeot, BS Glicksberg, L Trupin, D Lituiev… - JAMA network …, 2019 - jamanetwork.com
Importance Knowing the future condition of a patient would enable a physician to customize
current therapeutic options to prevent disease worsening, but predicting that future condition …

[HTML][HTML] Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update

MA Stoffer, MM Schoels, JS Smolen… - Annals of the …, 2016 - ard.bmj.com
Objective A systematic literature review (SLR; 2009–2014) to compare a target-oriented
approach with routine management in the treatment of rheumatoid arthritis (RA) to allow an …

[HTML][HTML] Application and pharmacological mechanism of methotrexate in rheumatoid arthritis

Z Zhao, Z Hua, X Luo, Y Li, L Yu, M Li, C Lu… - Biomedicine & …, 2022 - Elsevier
Methotrexate (MTX) has been used for the treatment of rheumatoid arthritis (RA) for about
forty years and to date MTX remains the part of global standard of treatment for RA. The …

Do depression and anxiety reduce the likelihood of remission in rheumatoid arthritis and psoriatic arthritis? Data from the prospective multicentre NOR-DMARD study

B Michelsen, EK Kristianslund, J Sexton… - Annals of the …, 2017 - ard.bmj.com
Objective To investigate the predictive value of baseline depression/anxiety on the
likelihood of achieving joint remission in rheumatoid arthritis (RA) and psoriatic arthritis …

Rheumatoid arthritis disease activity predicting incident clinically apparent rheumatoid arthritis–associated interstitial lung disease: a prospective cohort study

JA Sparks, X He, J Huang, EA Fletcher… - Arthritis & …, 2019 - Wiley Online Library
Objective To evaluate rheumatoid arthritis (RA) disease activity and risk of RA‐associated
interstitial lung disease (RA‐ILD). Methods We investigated disease activity and risk of RA …

Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection

M Biggioggero, C Crotti, A Becciolini… - Drug design …, 2018 - Taylor & Francis
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by articular and
systemic manifestations, such as anemia, fatigue, osteoporosis, and increased risk for …

Abatacept: a review in rheumatoid arthritis

HA Blair, ED Deeks - Drugs, 2017 - Springer
The biological DMARD (bDMARD) abatacept (Orencia®), a recombinant fusion protein,
selectively modulates a co-stimulatory signal necessary for T-cell activation. In the EU …