Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …

Genetic instability, which includes both numerical and structural chromosomal
abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements …

Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …

Human beings are made of~ 50 trillion cells which arise from serial mitotic divisions of a
single cell-the fertilised egg. Remarkably, the early human embryo is often chromosomally …

Chromosome segregation errors cause aneuploidy and genomic heterogeneity, which are
hallmarks of cancer in humans. A persistent high frequency of these errors (chromosomal …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Chromosomal instability (CIN)—which is a high rate of loss or gain of whole or parts of
chromosomes—is a characteristic of most human cancers and a cause of tumour aneuploidy …

Whole-chromosome copy number alterations, also known as aneuploidy, are associated
with adverse consequences in most cells and organisms. However, high frequencies of …

Copy number variants (CNVs) were the subject of extensive research in the past years. They
are common features of the human genome that play an important role in evolution …

Cancer is one of the leading causes of death, and despite increased research in recent
years, control of advanced-stage disease and optimal therapeutic responses remain elusive …