Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

The peroxisome proliferator-activated receptors (PPAR-α, PPAR-β/δ, and PPAR-γ) are
members of the nuclear receptor super-family, acting as ligand-inducible transcription …

Thyroid hormone (TH) is required for normal development as well as regulating metabolism
in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially …

Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid
hormone and their structural and functional analysis revealed an evolutionarily conserved …

Dietary intake and tissue levels of carotenoids have been associated with a reduced risk of
several chronic diseases, including cardiovascular diseases, type 2 diabetes, obesity, brain …

Abstract The “metabolic syndrome”(MetS) is a clustering of components that reflect
overnutrition, sedentary lifestyles, and resultant excess adiposity. The MetS includes the …

Hepatic metabolic derangements are key components in the development of fatty liver,
insulin resistance, and atherosclerosis. SIRT1, a NAD+-dependent protein deacetylase, is …

In multicellular organisms, the ability to regulate reproduction, development, and nutrient
utilization coincided with the evolution of nuclear receptors (NRs), transcription factors that …

The metabolic syndrome encompasses metabolic and cardiovascular risk factors which
predict diabetes and cardiovascular disease (CVD) better than any of its individual …