The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …

Cancer vaccines have emerged as a powerful new tool for cancer immunotherapy.
Adjuvants are vaccine ingredients that enhance the strength, velocity, and duration of the …

Intravenously administered cyclic dinucleotides and other STING agonists are hampered by
low cellular uptake and poor circulatory half-life. Here we report the covalent conjugation of …

The often immune-suppressive tumor microenvironment (TME) may hinder immune evasion
and response to checkpoint blockade therapies. Pharmacological activation of the STING …

The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer
treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the …

Pharmacological activation of the stimulator of interferon genes (STING) pathway has
become a promising strategy for cancer immunotherapy. However, the insufficient tumorous …

Abstract Tumour-associated macrophages (TAMs), as one of the most abundant tumour-
infiltrating immune cells, play a pivotal role in tumour antigen clearance and immune …

The tumor-associated vasculature imposes major structural and biochemical barriers to the
infiltration of effector T cells and effective tumor control. Correlations between stimulator of …

Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …

Cancer radio-immunotherapy, integrating external/internal radiation therapy with immuno-
oncology treatments, emerges in the current management of cancer. A growing number of …